N Propyl iodide

Deghenghi et al studied the reductive alkylation of 16-dehydropregneno-lone acetate in ammonia-tetrahydrofuran using excess lithium and alkyl iodides. Alkylation with methyl iodide followed by reacetylation of the 3-hydroxyl group affords 17a-methylpregnenolone acetate in 20% yield after purification by column chromatography. Ethyl iodide affords the 17a-ethyl analog in 40% yield, but n-propyl iodide affords the 17a-propyl compound in only a 12 % yield. 

FLUOROPROPANE ISOPROPYL IODIDE n-PROPYL IODIDE ALLYAMINE PROPYLENEIMINE N,N-DIMETHYLFORMAMIDE M-METHYLACETAMIDE... 

Propylbenzene, see Propylbenzene Propyl carbinol, see 1-Butanol Propylene aldehyde, see Acrolein, Crotonaldehyde Propylene chloride, see 1,2-Dichloropropane Propylene dichloride, see 1,2-Dichloropropane a,p-Propylene dichloride, see 1.2-Dichloropropane 1,2-Propylene oxide, see Propylene oxide Propyl ester of acetic acid, see Propyl acetate Propylethylene, see 1-Pentene 5-Propylhexane, see 4-Methyloctane Propyl hydride, see Propane Propylic alcohol, see 1-Propanol Propyl iodide, see 1-Iodopropane n-Propyl iodide, see 1-Iodopropane Propylmethanol, see 1-Butanol Propyl methyl ketone, see 2-Pentanone n-Propyl nitrate, see Propyl nitrate... 

Olivetol. (5-Alkyl Resourcinol) BER 69, 1644 (1936). Mix 25 g of ethyl-3,4,5-trimethoxy benzoyl acetate and 2.0 g of clean sodium in 100 ml ethanol and warm to react. Add 2 g n-propyl iodide (this may be replaced with n-amyl iodide) and heat on a steam bath for 12 hours, then neutralize and remove the ethanol by distillation. Extract the residue with ether, dry, and evaporate in vacuo to get 30 g of the alkyl acetate. Heat 22 g of this acetate in 5% KOH ethanolic solution for 1 hour at 50° and let stand to precipitate 14 g of 3,4,5-trimethoxyvalerophenone. Mix 11 g of the above product with 60 g of sodium in 600 ml ethanol. Warm and after dissolving the sodium add 2 liters of water. M e acidic with HCl acid and remove the ethanol by distillation. Extract with ether, dry, and evaporate the ether in vacuo to get if. g olivetol dimethyl ether. To demethylate this ether add it to 70 ml of hydrogen iodide and heat to boiling and reflux for two hours. Distill and keep the fraction at 160°-170° with 3-4 mm of vacuum applied to the distillation set-up. Yield about 6 g. 

All data obtained on the rate of reaction of [Ni(NiL2)2]Cl2 with alkyl halides— i.e., methyl iodide, benzyl bromide, benzyl chloride, p-nitrobenzyl chloride, p-chlorobenzyl chloride, ethyl bromide, ethyl iodide, n-propyl bromide, and n-propyl iodide—conform closely to a pseudo-first-order rate law. Almost all experiments were carried out in the presence of an excess of alkyl halide. Since methanol solutions of the alkylated complexes have only negligible absorption at 495 m//, rates were obtained by graphs of log A0—A vs. time. The graphs are linear over the entire time interval, which corresponds to more than two half lives in most cases, passing through the origin at zero time. The rate is essentially the same whether measured by the spectrophotometric or conductivity method. 

Zinc Dipropyl. Zn(C3H7)2, C6H14Zn mw 151.5 5 mobile pyrophoric liq, stable in a sealed tube under C02 bp 160° d 1.1034g/cc at 20/4° RI 1.4845 at 18.6°. Sol in org solvents decomps explosively on contact with w. Prepn is by reacting n-propyl iodide with Zn. The compd has a heat of combstn of 11133 5.6 kcal/mole(Refs3,p 181 6, p 491M-444)... 

Hydrazones prepared from (S)- l-amino-2-(methoxymethyl)pyrrolidine (242) and acyclic ketones have been shown to undergo deprotonation and alkylation with almost complete asymmetric induction at the a-center (79AG(E)397). The ant alarm pheromone, (+)-(5)-4-methyl-3-heptanone (245), was prepared from the metallated hydrazone of diethyl ketone (243) by alkylation with n-propyl iodide and subsequent cleavage of the crude product via its JV-methyl iodide with acid (Scheme 52). The optical purity of the product was >99%. 

Alkyl halides, acyl halides, anhydrides, and related substances. It was discovered as early as 1861 by Rcboul and Luurenool<4t> that epicblorohydrin may be caused to react with ethyl bromide on heating in a sealed tube to an elevated temperature. The product isolated from this condensation was ]-broJHo-3-chloro-2-ethoxyprt>pane. Some year later Paalli6 extended this reaction to include also methyl iodide, ethyl iodide, n-propyl iodide, and isopropyl iodide do2-propunol was formed. 

AB98 C3H7I n-propyl iodide 13 CH3CH2CH2I EtOH 50 PY Et4NI 0.1 - 25 DME/SCE 13A1 "... 

Figure 4.8 Hydrocarboxylation and carbonylation of propylene and n-propyl iodide. The outer cycle is the hydrocarboxylation pathway, while the inner cycle is the carbonylation pathway. The carbonylation pathway generates only n-butyric acid iodide. Note that 4.27 is identical with 4.5. A different designation is used to avoid cross-...

Although at a first glance the cycles may appear to be too complex, most of the catalytic species are analogues of intermediates shown in Fig. 4.2. Complexes 4.24 and 4.27 are oxidative addition products of 4.1 with n-propyl iodide and HI, respectively. 

Chiral di- and tripropyl ethers, 59b and 60b for example, have been synthesized as shown in Figure 14.121 Complete O-alkylation of the monobenzyl ether was possible with n-propyl iodide in THF/DMF with NaH as base. The cone and the partial-cone conformers were formed in a 1 1 ratio and could be separated chroma-tographically. Alkylation with n-propyl bromide in the presence of Cs2C03 in acetone gave the di-O-propylated compound 59a, in which both propoxy groups in anti orientation, in good yield. The cleavage of the benzyl ether with trimethylsilyl bromide led to the final products 59b and 60b. 

Asymmetric a-alkylatlon of ketones (7, 10-11 8, 16-17). Enders and Eichenauer have now obtained almost complete asymmetric a-alkylation of acyclic ketones by way of hydrazones formed with 1. An example is the synthesis of (+)-(S)-4-methyl-3-heptanone (4), an ant alarm pheromone, from diethyl ketone. The hydrazone 2 was metalated and alkylated with n-propyl iodide in ether to give 3. 

The lack of laser action in the photolysis of isopropyl iodide raises intriguing questions. As Husain and Donovan point out, this does not necessarily indicate the absence of population inversion, since under the laser experimental conditions there could instead be an insufficient absolute concentration of I atoms. Spectroscopic studies show that excited iodine atoms are produced from isopropyl iodide photodissociation, but at lower relative concentrations than for n-propyl iodide under similar conditions. Since the two propyl iodides show similar I quenching rates, it would appear most likely that a decreased I /I ratio is the reason stimulated emission is not seen. The present experiments, unfortunately, cannot provide a more quantitative explanation. The distinct broadness of the isopropyl iodide distribution in fig. 2 indicates a departure from the methyl- ethyln-propyl trend, and might represent comparable amounts of P and I atom production, with overlapping translational energy distributions, at least when viewed with our present... 

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