Propionitrile, 0-amino

Propionic acid, /J-(chloroformyl)-, METHYL ESTER, 25, 19 Propionic acid, /J,/S -methyliminobis, DIETHYL ESTER, 20, 35 Propionic anhydride, 21, 14 Propionitrile, /3-amino-, 27, 3 Propionitrile, 6-ETHOXY-, 23, 33 Propionitrile, 6,6 -iminodi-, 27, 3 Propionyl chloride, 24, 30 Propiophenone, 6-diethylamino-, 23, 31... 

The first synthesis and use of a chiral oxazoline was reported by Meyers in 1974. The chiral oxazoline 1 was prepared in two steps by condensation of (-i-)-l-phenyl-2-amino-1,3-propanediol (6) with the ethyl imidate of propionitrile followed by 0-methylation of the resulting alcohol 7 with NaH/Mel. Meyers demonstrated chiral oxazoline 1 could be... 

Reduction of 3-benzyl-8-chloro-4-oxo-4//-pyrido[l,2- ]pyrimidine-2-carboxylate <2004W004/064741> and 2-methyl-4-oxo-4//-pyrido[l,2-tf]pyrimidine-3-carboxylate <2003T4123> with DIBAL-H afforded 2- and 3-formyl derivatives, respectively. Reduction of /V-(4-fluorobenzyl)-3-hydroxy-8-[methoxy(methyl)amino]-4-oxo-6,7,8,9-tetra-hydro-4//-pyrido[l,2- ]pyrimidine-2-carboxamide with Zn-dust in aqueous AcOH afforded the 8-methylamino derivative, which was acylated with AcOH in the presence of Hiinig s base, HOBt, and l-(3-dimethylaminopro-pyl)-3-ethylcarbodiimide-HCl <2004W004/058756>. 3-(Perhydropyrido[l,2- ]pyrimidin-2-yl)propylamine was obtained by catalytic hydrogenation of 2-(perhydropyrido[l,2- ]pyrimidin-2-yl)propionitrile over a Pt02 catalyst <2003FRP1275647>. 

Propionitrile, 51 -Propylacetylene, 17 2,3-Pyrazinedicarboxylic acid, 86 Pyridine, 3-amino, 3 Pyridine, 5-ethyl-2-methyl, 41 Pyruvic aldehyde-sodium bisulfite, 88... 

De-2-methyl propionitrile or 2-amino-4-chloro-6-isopmpylamino-.v-triazine cyanazine Deethylsimazine... 

Alanine has been prepared by the catalytic reduction of cyanoacetic esters 1 or salts 2 by heating acrylonitrile,3 /3-amino-propionitrile,4 iw-(/3-cyanoethyl)-amine,5 /3-hydroxypropionitrile, /3-alkoxypropionitriles,7 u.s-(/3-cyanocthyl) ether,8 or bis-(fi-cyano-ethyl) sulfide 8 with aqueous ammonia at 150-225° by the hydrolysis of /3-aminopropionitrile with concentrated hydrochloric acid and subsequent removal of the acid with anion exchange resins.9 The method as described above has been published.10 Additional references to methods of preparation are given in connection with a procedure for the making of /3-alanine from suc-cinimide through the action of potassium hypobromite.11... 

The first known synthesis of an amino acid occurred in 1850 in the laboratory of Adolph Strecker in Tubingen, Germany. Strecker added acetaldehyde to an aqueous solution of ammonia and HCN. The product was a-amino propionitrile, which Strecker hydrolyzed to racemic alanine. 

CHLORO-4-ETHYLAMINO-6-ISOPROPYLAM1NO-1,3,5-TRIAZINE see ARQ725 2-(4-CHLORO-6-ETHYLAMINO-s-TRIAZINE-2-YLAMINO)-2-METHYL-PROPIONITRILE see BLW750 2-(4-CHLORO-6-ETHYLAMINO-l,3,5-TRIAZINE-2-YLAMINO)-2-METHYLPROPIONITRILE see BLW750 2-((4-CHLORO-6-(ETHYLAXflNO)-l,3,5-TRIAZIN-2-YL)AMINO)-2-METHYL-PROPANENITRILE see BLW750... 

Other Addition Reactions - The photochemical addition in the gas phase of ammonia to a,P-unsaturated nitriles has been studied. The reactions are carried under conditions where all, or most, of the light is absorbed by the ammonia and this results in N-H bond fission and the production of NH2 radicals. These radicals add to the a-position of the substrate to yield 2-amino-propionitrile from acrylonitrile and analogous products are formed from crotononitrile, methacrylonitrile and 1-cyclohexenecarbonitrile. Additions also occur to but-2-yne nitrile which yields the Z, -isomers of 3-amino-crotononitrile with the E -isomer being predominant. The SET-induced amina-tion (using 1,4-dicyanobenzene as the sensitiser) of alkenylnaphthalene derivatives affords products of addition to both the alkene and the naphthalene skeleton. Suau et al. have examined the irradiation of phthalimide in the presence of low concentrations of hydroxide ion and alkenes. ° The result of this treatment is addition of the phthalimide moiety to the alkene. A SET... 

L-(+)-2-Amino-2-methyl-3-(3,4-dimethoxyphenyl)propionitrile (5)-(+)-2-Amino-3-methyl-1 -pentanol (l-(+)-Isoleucinol) (77)-(—)-2-Amino-4-methyl-1 -pentanol (d-(—)-Leucinol)... 

Following their work on the synthesis of the parent compound 2,6-naphthyridine (105) (105). Taurins and Li reported their work in full (107) and at the same time reported a synthesis of the 4-methyl derivative 104, isolated by Harkiss and Swift (62). 4-Cyano-3-pyridyl-acetonitrile (275) was methylated (CFLI-NaOQHs) in the side chain to afford 2-(4-cyano-3-pyridyl)propionitrile (276), which was treated with hydrogen bromide in ether to afford 3-amino-l-bromo-4-methyl-2,6-naphthyridine (277). Diazo-tization/bromination and replacement of the bromine groups with hydrazine gave 278, and reaction with CuS04 in acetic acid afforded 4-methyl-2,6-naphthyridine (98) (Scheme 23) (107), whose spectroscopic properties were identical with those reported previously (62,63). 

Aminodimethylacetonitrile a-Aminoisobutyronitrile 2-Amino-2-methylpropanenitrile 2-Amino-2-methyl-propiononitrile 2-Aminoisobutyronitrile 2-Cyano-isopropylamine EINECS 242-989-3 Propanenitrile, 2-amino-2-methyl- Propionitrile, 2-amino-2-methyl- Vazo 64AN. 

---