5- Methoxy-l-methyl

Imidazole, 1 -hydroxy-2,4,5-triphenyl-3-oxides reactions, S, 455 Imidazole, iodo-nitrodehalogenation, 5, 396-397 Imidazole, 1-iodo-reactions, S, 454 stability, S, 110 Imidazole, 2-iodo-synthesis, S, 401 Imidazole, N-iodo-, S, 393 reactions, 5, 454 Imidazole, 4-iodo-5-methyl-iodination, 5, 400 Imidazole, 2-isopropyl-4-nitro-N-nitration, 5, 351 Imidazole, 2-lithio-reactions, S, 106, 448 Imidazole, 2-mercapto-l-methyl-as antithyroid drug, 1, 171 mass spectra, 5, 358 Imidazole, 1-methoxymethyl-acylation, S, 402 Imidazole, 5-methoxy-l-methyl-reactions... 

Indole, 3-hydroxymethyl-2-phenyl-stability, 4, 272 Indole, I-hydroxy-2-phenyl-synthesis, 4, 363 Indole, 2-iodo-synthesis, 4, 216 Indole, 3-iodo-reaetions, 4, 307 synthesis, 4, 216 Indole, 2-iodo-l-methyl-reaetions, 4, 307 Indole, 2-lithio-synthesis, 4, 308 Indole, 3-lithio-synthesis, 4, 308 Indole, 2-mereapto-tautomerism, 4, 38, 199 Indole, 3-mercapto-tautomerism, 4, 38, 199 Indole, 3-methoxy-synthesis, 4, 367 Indole, 5-methoxy-oxidation, 4, 248 Indole, 7-methoxy-2,3-dimethyl-aeetylation, 4, 219 benzoylation, 4, 219 Indole, 5-methoxy-l-methyl-reduetion, 4, 256 Indole, 5-methoxy-l-methyl-3-(2-dimethylaminoethyl)-reaetions... 

Acetaldehyde has been used in the condensation with a large number of substituted tryptophans, including the 4-, 5-, 6-, and 7-methoxy4-methoxy-l-methyl and 5-methoxy-l-methyl ... 

A spiro indoline (347) has been isolated from the reaction of the quaternized derivative of 5-methoxy-l-methyl-3-(2-dimethylaminoethyl)indole with lithium in liquid ammonia in the absence of a proton donor (68TL81). The product presumably arises from the rapid sequential addition of two electrons to generate the dianion of the tryptamine, which facilitates the nucleophilic displacement of trimethylamine. Reduction in the presence of methanol produces the 4,7-dihydrotryptamine (see Section 3.05.1.5). 

Indolequinolyl derivative 3-(5-methoxy-l-methyl-4,7-indolequinonyl) methyl N,N-bis(2-bromoethyl)phosphorodiamidate was also prepared by the author as illustrated in Eq. 1 ... 

Hydroxy-l -methy P2-oxo-3,5-diphenyI-l, 2-dihydio 3-Isobutyl-l-methyl-2-0X0-1,2-dihydio 3-IsopropyH-raethyl-2-oxo-l, 2-dihydio 3-Methoxy-l-methyl-2-0X0-1,2-[Pg.461]

A rate study of benzimidazoles with weak electron-donating groups showed that the rate of the Chichibabin amination decreased as the strength of the electron-donating character increased (i.e., 1,5-dimethyl > 5-methoxy-l-methyl > 1,5,6-trimethylbenzimidazole) (77CHE903). Because the substrates do not contain sterically hindered substituents, the rate decrease is a function of the increased electron density in the system, particularly the decreased effective positive charge at the 2-position. 

Methoxy-l-methyl-indol liefert mit Lithium/Ammoniak/THF und Nachbehandlung mit Eisen(III)-chlorid (Unterbinden von Uberreduktion) 5-Methoxy-1-methyl-2,3-dihydro-indol (70% d.Th.), wahrend mit Lithium/Ammoniak/Methanol in 60%-iger Ausbeute 5-Methoxy-1 -methyl-4,7-dihydro- neben nur 5% -2,3-dihydro-indol entstehen3,4. 

Methoxy- 2-methyl-3-(2-amino-athyI)- 1-benzyl- 589 5-Mcthoxy-2-methyl-3-cyanmethyl-1-benzyl- 589 5-Methoxy- l-methyl-2,3-dihydro- 640 5-Methoxy-l-methyl-4,7-dihydro- 640... 

M.A. Naylor, E. Swann, S.A. Everett, M. Jaffar, J. Nolan, N. Robertson, S.D. Lockyer, K.B. Patel, M.F. Dennis, M.R.L. Stratford, P. Wardman, G.E. Adams, C.J. Moody and I.J. Stratford, Indolequinone anti-tumor agents reductive activation and elimination from (5-methoxy-l-methyl-4,7-dioxoindol-3-yl)methyl derivatives and hypoxia-selective cytotoxicity in vitro, J. Med. Chem., 41 (1998) 2720. 

Methoxy-l -methyl-hydantoin-methyl iinid-(4)-oarbonB ure-(5) ainid 2S 1604,... 

Methoxy-l methyl i ydantoin.mrbon> a nre-(5)- thylamid 26 II270. 

Methoxy-l-methyl-hydaiitoin-methyl itmd-(4).carbons ure-(5)-methylamid 25 n 271. 

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