Phenyl 2-propenyl

Chemical Name 1-(diphenylmethyl)-4-(3-phenyl-2-propenyl)piperazine... 

The diastereoselectivity for the addition of (3-phenyl-2-propenyl)magnesium chloride21 and 2-butenylmagncsium bromide22 to benzaldehyde is low and, surprisingly, syrt-4 is the major product. 

Trimethyl(l-phenyl-2-propenyl)silane of high enantiomeric excess has also been prepared by asymmetric cross coupling, and reacts with aldehydes to give optically active products in the presence of titanium(IV) chloride. The stereoselectivity of these reactions is consistent with the antiperiplanar process previously outlined75. 

The lithium enolates of cyclopentanone and cyclohexanone undergo addition-elimination to the 2,2-dimethylpropanoic acid ester of ( )-2-nitro-2-hepten-l-ol to give 2-(l-butyl-2-nitro-2-propenyl)cycloalkanones with modest diastereoselection. An analogous reaction of the enolate ion of cyclohexanone with the 2,2-dimethylpropanoic acid ester of (Z)-2-nitro-3-phenyl-2-propenol to give 2-(2-nitro-l-phenyl-2-propenyl)cyclohexanones was also reported. The relative configuration of these products was not however determined6. 

Thiazole, 4,5-dihydro-2-[[l-(phenylmethyl)-2-propenyl] thio] - [52534-824], 78 Thiazole, 4,5-dihydro-2-[(phenylmethyl)-thio] - [41834-62-2], 82 Thiazole, 4,5-dihydro-2-[(3-phenyl-2-propenyl)thio] - [57620-95-8], 82 Thiazole, 4,5-dihydro-2-(2-propenylthio)-[3571-74-2],77... 

CN ( )-( )-l,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl 3-phenyl-2-propenyl ester... 

Another reaction performed in the dead-end reactor discussed before, is the allylic amination of 3-phenyl-2-propenyl-carbonic acid methyl ester with morpholine. [30] First and second generation commercially available DAB-dendrimers were functionalized with diphenylphosphine groups (Figure 4.13). Two different membranes were used, the Nadir UF-PA-5 (ultrafiltration) and the Koch MPF-50 (former SELRO) (nanofiltration), which gave retentions of 99.2% and 99.9% respectively for the second generation functionalized dendrimers. 

Dihydro-6- [3-(2-hydroxymethyl)-phenyl-2-propenyl]-5-benzofuranol +0.55 glassy carbon 264... 

Another example is the palladium catalyzed allylic substitution of 3-phenyl-2-propenyl-carbonic acid methyl ester to yield iV-(3-phenyl-2-propenyl)morpho-line reported by Reetz, Kragl and co-workers. This reaction was performed in the presence of phosphino-terminated amine dendrimers [17, 18] loaded with Pd11 cations as shown in Scheme 10. For this particular dendrimer with a molecular weight of 10 212 g/mol, a retention of 0.999 per residence time [35] was estimated in a membrane reactor with a SELRO MPF-50 membrane. It must be noted that a very high retention is a prerequisite for a continuous operating system, since a small leaching of the dendrimer leads to an exponential decrease in the amount... 

In a radical reaction of 2-iodomethylpiperidine (112) with tributyltin hydride, 2-(3-phenyl-2-propenyl)piperidine (113) and a 1 1 mixture of epi-mers of perhydropyrido[l,2-6][l,2]thiazine-l,1-dioxide (114) were obtained in 18 and 47% yield, respectively (77TL635). An identical mixture of 113 and the two epimers of 114 was also obtained from a 7 4 mixture of the Z and E isomers of 112, indicating that the starting C=C geometry is not maintained in the product 114. 

Naftifine Naftifine, (E)-N-methyl-N-(3-phenyl-2-propenyl)-1 -naphthalinmethanamine (35.3.1), is synthesized by alkylating N-methyl-(l-naphthylmethyl)-amine with cinnamyl chloride in the presence of sodium carbonate [38 3]. 

E)-3-[(E)-3-Phenyl-2-propenoxy]acrylic acid 2-Propenoic acid, 3-[(3-phenyl-2-propenyl)oxy] -, (E,E)- (10) (88083-18-5)... 

Chiral (5)-2-(methoxymethyl)-l -[( )-3-phenyl-2-propenyl]pyrrolidine obtained from (S)-2-(meth-oxymethyl)pyrrolidine26,30 and ( )-3-bromo-1-phenyl-1-propene, is deprotonated by potassium rert-butoxide/ferf-butyllithium27-28 generating the chiral allyl carbanion, the alkylation of which affords the enamines, which can be hydrolyzed to give 3-alkylated 3-phenylpropanals. 

To a suspension of 2.24 g (20 mmol) of potassium rerf-butoxide in 20 mL of terf-butyl methyl ether under argon is added 2.31 g (10 mmol) of (S)-2-(methoxymethyl)-1-[( )-3-phenyl-2-propenyl]pyrrolidine30, and then the mixture is cooled lo — 78 °C and 7.1 mL of 1.69 M fm-butyllithium in pentane is added dropwise with stirring. After 2 h, 12 mmol of the haloalkane are added and the mixture is stirred until the brown-red solution becomes yellow. Then 30 mL of diethyl ether and 20 mL of 2 N hydrochloric acid are added, the mixture stirred for 12 h at 25 °C, extracted with three 40-mL portions of CH2CI2, the organic layer is washed with two 10-mL portions of NaHCOj and two 10-mL portions of water, dried with Na2S04, concentrated in vacuo and distilled (Kugelrohr). 

By comparison with the known values of optical rotation the configuration at C-3 of the predominant enantiomer of the 3-phenylalkanoic acid was R in most cases (CIP rules dependent). Therefore, a bicyclic structure of the dilithio compound, in analogy to that proposed for the deprotonated 3-phenyl-2-propenyl ether21, which is alkylated in a metalloinversive reaction mode seems to be reasonable. 

Chem. Abstr. Name 3-Phenyl-2-propen-l-ol, 2-aminobenzoate lUPAC Systematic Name Anthranilic acid, cinnamyl ester Synonyms Cinnamyl alcohol anthranilate 3-phenyl-2-propenyl 2-aminobenzoate 3-phenyl-2-propenyl anthranilate... 

Phenyl-2-propenyl acetate, AT49 3-Phenylpropionaldehyde, AP31... 

Chemical Name lH-Indole-3-acetic acid, 5-methoxy-2-methyl-l-(l-oxo-3-phenyl-2-propenyl)-... 

Chemical Name Benzenemethanol, a-(l-(methyl(3-phenyl-2-propenyl) amino)ethyl)-, hydrochloride... 

Chemical Name l-[Bis(4-fluorophenyl)methyl]-4(3-phenyl-2-propenyl) piperazine hydrochloride... 

Phenyl 3-phenyl-2-propenyl ethers 448, which feature a latent oxonium ion functionality, cyclize upon treatment with acid to afford the chroman 449 as a mixture of diastereomers. Reduction of the chroman 449 with Raney nickel affords a single diastereomeric product 450 (Scheme 102) <2005TL3719>. 

We recently reported a convenient and efficient synthetic route to new 3-substituted 2,3-dihydrobenzo[h]furans 278 based on the tandem cyclization-y-alkylation of 2-bromophenyl ( )-3-phenyl-2-propenyl ether 276 whose operational simplicity could find favor in many applications161. Previous attempts using 2-bromophenyl (E)-2-propenyl ether failed because the cyclic intermediate underwent a y -elimination. We thought that a likely strategy to overcome the y-elimination in the cyclic (2,3-dihydrobenzo[h]furanyl)methyllithium intermediate could be substitution by a phenyl moiety that could provide increased resonance stabilization to the cyclic lithium intermediate 277 (Scheme 85). 

The first intermolecular C-N bond-forming reactions between substituted 2-bromopyrroles 1450 and 1453 with primary (Tpropanamine, 2-methoxy-l-ethanamine, (4-methoxyphenyl)methanamine, cyclopropanamine, cyclobuta-namine), and cyclic secondary amines (pyrrolidine, morpholine, 1-methylpiperazine, ethyl tetrahydro-l(27/)-pyrazi-necarboxylate, 1-phenylpiperazine, l-(3-phenyl-2-propenyl)piperazine) 1451 were performed using Pd2(dba)3 as catalyst with BINAP as the ligand. The aminations proceeded in the presence of Bu ONa at 80-100 °C in 31-93% yields (Equations 301 and 302) <2004TL769>. However, when the above optimized conditions were applied to the coupling reaction of pyrrole 1450 and acyclic secondary amines such as di- -butylamine, diphenylamine and dipropenylamine, no reaction was observed. 

Diazetidin 3-Oxo-l-(3-phenyl-2-propenyl)- El 6c, 977 (aus 1-Alky-liden-2-dehydro-l, 2-diazetidin) Hexansaure 5-Oxo-4-(2-pyridyl)- ... 

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