Prolactin releasing hormone

Corticotropin-Releasing Hormone (CRH or CRF) Melanotropin-Releasing Hormone (MRH) Prolactin-Releasing Hormone (PRH)... 

Prolactin-releasing hormone (PRH) Prolactin (PRL) Lymphocytes Lymphokines... 

PRH acronym of Prolactin Releasing Hormone (see Releasing hormones). 

Prolactin releasing factor (PRF), prolactin releasing hormone, prolactoliberin a hormone thought to be identical with thyrotropin releasing factor, llie structure of Prolactin release inhibiting hormone (PIH) (prolactostatin) is unknown. PRF promotes, whereas PIH inhibits the synthesis and secretion of prolaction by the anterior pituitary. 

Takahara J, Yunoki S, Yakushiji W, et ah Stimulatory effects of gamma-hydroxybutyric acid on growth hormone and prolactin release in humans. J Clin Endocrinol Metab 44 1014-1017, 1977... 

Prolactin is an essential hormone for normal production of breast milk following childbirth. It also plays a pivotal role in a variety of reproductive functions. Prolactin is regulated primarily by the hypothalamus-pituitary axis and secreted solely by the lactotroph cells of the anterior pituitary gland. Under normal conditions, secretion of prolactin is predominantly under inhibitory control by dopamine and acts on the D2 receptors located on the lactotroph cells. Increase of hypothalamic thyrotropin-releasing hormone (TRH) in primary hypothyroidism can stimulate the release of prolactin. 

In addition to the classical stress hormones already reviewed, several other hormones are augmented in response to stress. Stress-induced prolactin release is one of the most frequently studied examples. There is no doubt about the causal relationship between stress and increased pituitary prolactin release, but the biological meaning is much less clear (G2). This phylogenetically old hormone has been shown to have more than 85 different functions in all vertebrate species. However, besides its role in the induction of maternal lactogenesis, the physiological importance of prolactin is at present not fully established. Experimental and clinical evidence supports the view that prolactin is also an immunoregulating hormone (M44, R18). Prolactin receptors are present on human T and B lymphocytes (R18), and T lymphocytes depend on prolactin for maintenance of immunocompetence (B19). In addition, it has been shown that prolactin is able to influence the devel-... 

The release of prolactin from the adenohypophysis is normally inhibited by prolactin-inhibiting hormone (PIH, dopamine) from the hypothalamus. Prolactin secretion is also controlled by prolactin-releasing factor (PRF). The release of PRF from the hypothalamus is mediated by reflexes elicited by suckling and breast stimulation. 

Prolactin A hormone released from the anterior pituitary. 

The response of prolactin (PRL) to the hypothalamic TSH-releasing hormone (TRH) and to insulin hypoglycemia is reduced in long-term Li+-treated patients, as is the response of growth hormone to insulin hypoglycemia however the concentration of growth hormone is also reported to be elevated during Li+ treatment [170]. 

The dopamine D2 agonists bromocriptine and cabergoline (pp. 114, 188) inhibit prolactin-releasing AH cells (indications suppression of lactation, prolactin-producing tumors). Excessive, but not normal, growth hormone release can also be inhibited (indication acromegaly) (3). 

Anterior part produces its own hormones in response to hypothalamic releasing hormones, e.g., adrenocorticotropic hormone ACTH, luteinizing hormone LH, follicle-stimulating hormone FSH, prolactin, growth hormone, thyroid-stimulating hormone TSH Thyroid Regulation of metabolism, development, and maturation... 

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