Prolactin releasing factor

The release of prolactin from the adenohypophysis is normally inhibited by prolactin-inhibiting hormone (PIH, dopamine) from the hypothalamus. Prolactin secretion is also controlled by prolactin-releasing factor (PRF). The release of PRF from the hypothalamus is mediated by reflexes elicited by suckling and breast stimulation. 

Prolactin (PRL) Protein, MW 20,000 Prolactin release factor (PRF) may or may not be identical to thyrotropin-releasing hormone Prolactin release-inhibiting factor (PIF) most likely dopamine Supports lactation... 

PIH (Dopamine) Prolactin Releasing Factor (PRF) (153) unknown (Arcuate, VMN) inhibitsLH,FSH release Stimulates PRL release (D2)... 

The existence prolactin-releasing factor (PRF), a yet-to-be-characterized stimulator of PRL release, remains controversial, particularly in view of the fact that TRH subserves this role. What is clear, however, is that the... 

Like other anterior pituitary hormones, prolactin is secreted in a pulsatile manner. Prolactin is unique among the anterior pituitary hormones in that hypothalamic regulation of its secretion is predominantly inhibitory. The major regulator of prolactin secretion is dopamine, which is released by tuberoinfundibular neurons and interacts with the Dj receptor on lactotropes to inhibit prolactin secretion. A number of putative prolactin-releasing factors have been described, but their physiological roles are unclear. Under certain pathophysiological conditions, such as severe primary hypothyroidism, persistently elevated levels of TRH can induce hyperprolactinemia and consequent galactorrhea. 

Prolactoliberin, pro/act/n-re/eas/ng hormone (PRH), prolactin-releasing factor (PRF), a hypothalamic substance (with for a long time an unknown structure) that stimulates the release of prolactin in the adenohypophysis. Although the release of prolactin is stimulated by other peptides such as —thyroliberin (TRH), VIP, PACAP, oxytocin, and vasopressin, it has been assumed that the prolactin-releasing peptide (PrRP) may function as prolactoliberin. Surprisingly, a dopamine-rdated stereospecific tetrahydroisoquinoline, termed salsolinol, 1 -methyl-6,7-dihydroxy-1,2,3,4-... 

Prolactin releasing factor (PRF), prolactin releasing hormone, prolactoliberin a hormone thought to be identical with thyrotropin releasing factor, llie structure of Prolactin release inhibiting hormone (PIH) (prolactostatin) is unknown. PRF promotes, whereas PIH inhibits the synthesis and secretion of prolaction by the anterior pituitary. 

Prolactin release-inhibiting factor (PIF) and prolactin-releasing factor (PRF) 183... 

Prolactin Release Inhibiting Factor. PIF. and Prolactin Releasing Factor. PRF - There is physiological evidence that the secretion of prolactin is under some sort of tonic inhibition by the hypothalainus ". Descriptions of attempts to purify this factor have placed it in or near the zone of material having LRF releasing activity in gel filtration experiments. LRF does not stimulate or inhibit the release of prolactin in vivo or vitro 63, No meaningful chemistry on the nature of this factor is available. 

Yasuda, N., and Greer, S. E., 1978, Conversion of high molecular weight GRF (corticotropin-releasing factor) or PRF (prolactin-releasing factor) into lower molecular weight forms by boiling at low pH, Biochem. Biophys. Res. Commun. 85 1291. 

---