Procyclidine

In much the same vein, the Mannich product from acetophenone with formaldehyde and pyrrolidine (44b) affords procyclidine (49) Dn reaction with cyclohexylmagnesium bromide. In an interesting variation, the ketone is first reacted with phenylmagnesium bromide. Catalytic hydrogenation of the carbinol (50) thus obtained iTin be stopped after the reduction of only one aromatic ring. ... 

Algestone acetophenide Biperiden Eprozinol Fendiline HCl Phenindamine tartrate Procyclidine HCl Pyrrobutamine Tridihexethyl iodide Trihexyphenidyl HCl m-Acetoxy acetophenone Norfenefrine... 

Clorazepate dIpotassium Cycrimine HCI Diphemanil methyl sulfate Feno profen Medazepam Procyclidine HCI Tamoxifen Tiemonium iodide 4-Bromobenzyl cyanide... 

Sila-procyclidine, (cyclohexyl)phenyl[2-pyrrolidin-l-yl]silanol, may be prepared by hydrolysis of the corresponding methoxysilane (220) and is interesting in that it can form two types of hydrogen-bonded structure depending on whether it is enantiomerically pure or a racemate. In the racemate, the compound forms centrosymmetric dimers of (R)- and (S)-configuration molecules with an 0---N distance of 1.791 A. In the pure (R)-compound, however, the molecules are linked into infinite chains via intermolecular 0-H---N hydrogen bonds (0---N distance 2.792 A) (221), again similar to those in (2-morpholinoethyl)diphenylsilanol shown in Fig. 3. 

Sila-biperidin rac-(SiRS, C2 SR), 35, can be prepared by hydrolysis of the corresponding methoxysilane and behaves in a similar way to sila-procyclidine The exo form has centrosymmetric dimers formed via a pair of intermolecular OH---N hydrogen bonds (0---N distance 2.810 A), while the endo form has intermolecular OH---N hydrogen bonds linking the molecules into infinite chains (222). 

Keywords behaviour guinea pig physostigmine, procyclidine pretreatment ... 

Drug solutions and implantation of osmotic mini-pumps Physostigmine hemisulphate and procyclidine hydrochlorid were obtained from Sigma (St.Louis, U.S.A.), scopolamine hydrobromid from Merck (Darmstadt, Germany), atropine sulphate was obtained from ACF (Amsterdam, The Netherlands), and diazepam from Roche (The Netherlands). HI-6 was made available by the Defence Research Establishment, Suffield, Canada. Soman (O-pinacolyl methylphosphonofluoridate) was synthesised at TNO. Alzet Osmotic Mini-pumps with a constant delivery rate of 0.55 pl/hr (Model 2002, Alza Corp., Palo Alto, USA) were used to deliver PYR, PHY and SCO. The vehicle consisted of 20% propylene glycol, 10% ethanol and 70% water. The pumps were implanted subcutaneously under isoflurane/02 inhalation anesthesia. 

Kim Y-B, Cheon K-C, Hur G-H, Phi T-S, Choi S-J, Hong D, Kang J-G. Effects of combinational prophylactics composed of physostigmine and procyclidine on soman-induced lethality, seizures and brain injuries. Environ. Toxicol. Pharmacol. 11(1) 15-21,2002. 

Procainamide 58 Procan 58 Procanbid 58 Procardia 52 Procardia-XL 52 Prochlorperazine 58 Proctocream 40 Proctocream HC 80 ProctoFoam HC 80 Procyclidine 58 Progesterone 80 Prdwin 36... 

Procyclidine Procyclidine, l-cyclohexyl-l-phenyl-3-pirrolidinopropan-l-ol (10.2.3), is synthesized in the exact same manner, except beginning with 2-(l-pyrroMmo) propio-phenone [28-32]. 

In terms of pharmacological properties, it basically does not differ from trihexyphenidyl. The most common synonym of procyclidine is cemadrin. 

The therapeutic value of these drags is relatively small, and they are nsed either in combination with levodopa, or in cases of minor Parkinsonism. Drags described in Chapter 10—trihexyphenidyl (10.2.2), procyclidine (10.2.3), biperiden (10.2.4), benztropine (10.2.6), ethopropazine (10.2.7), and others belong to this gronp of drugs. 

Drugs that may be affected by SSRIs Drugs that may be affected by SSRIs include alcohol, benzodiazepines, beta blockers, buspirone, carbamazepine, cisapride, clozapine, cyclosporine, diltiazem, digoxin, haloperidol, hydantoins, lithium, methadone, mexiletine, nonsedating antihistamines, NSAIDs, olanzapine, phenothiazines, phenytoin, pimozide, procyclidine, ritonavir, ropivacaine, sumatriptan, sulfonylureas, sympathomimetics, tacrine, theophylline, tolbutamide, tricyclic antidepressants, and warfarin. 

---