Tridihexethyl Iodide

Chemical Name 7 Cyclohexyl-N,N,N-triethyl-7-hydroxybenzene-propanaminium iodide Common Name Propethonium iodide tridihexethide Structural Formula  

Acetophenone, paraformaldehyde and diethylamine are first reacted to give CO-diethylamino-propiophenone. That is reacted with cyclohexylmagnesium bromide to give 3-diethylamino-1 -cyclohexyl-1 -phenylpropanol-1. 

320 parts of methyl isobutyl ketone is added 570 parts of 3-diethylamino-1 -cyclohexyl-1 -phenylpropanol-1 (2 mols) and the mixture is stirred until solution is complete. Then 500 parts (3.2 mols or 60% excess) of ethyl iodide are added. After filtration, the filtrate is diluted with an additional 300 parts of methyl isobutyl ketone and the solution is then heated at the reflux temperature (108°C to 110°C) for 9 hours. After cooling to 0°C, the precipitated solid material is removed by filtration, washed with isopropyl acetate and dried. Approximately 111 parts of product is obtained or a yield of 88.6% based on as-is starting material or 92.5% based on real starting material. 

Patent 2,913,494 November 1 7, 1959 assigned to American Cyanamid Co. 

Therapeutic Function Antineoplastic Chemical Name 2,4,6-Tris(1-aziridinyl)-s-triazine Common Name Tretamine Structural Formula  

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Algestone acetophenide Biperiden Eprozinol Fendiline HCl Phenindamine tartrate Procyclidine HCl Pyrrobutamine Tridihexethyl iodide Trihexyphenidyl HCl m-Acetoxy acetophenone Norfenefrine... 

Cyclomethycaine Oxyphencyclimine Tridihexethyl iodide Trihexyphenidyl HCl 2-Cyclohexylcarbonyl-4-oxo-2,3,6,7-tetrahydro-4H-pyrazino[2,1 -a] isoquinoline Praziquantel... 

Gallamine triethiodide Ibuprofen Nalidixic acid Oxetorone fumarate Oxolinic acid Piroheptine Rosoxacin Tridihexethyl iodide Ethyl 4-iodobutyrate Meptazinol... 

Algestone acetophenide Biperiden Eprozinol Fendiline HCI Phenindamine tartrate Procyclldine HCI Pyrrobutamine Tridihexethyl Iodide Trihexyphenidyl HCI m-Acetoxyacetophenone Norfenefrine... 

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