Procyclidine toxicity

PAROXETINE ANTIMUSCARINICS - DARIFENACIN, PROCYCLIDINE t levels of these antimuscarinics Inhibition of metabolism Watch for early features of toxicity... 

Procyclidine is an anticholinergic drug (1). The usual oral dose, which lies between 20 and 30 mg/day, is likely to produce only mild anticholinergic adverse effects, but involuntary movements, with chewing and sucking, have been described in some patients (SEDA-1, 120). Even small doses have produced toxic confusional states when procyclidine was combined with phenothiazines for schizophrenia. Procyclidine is more hkely to produce sedation than stimulation. 

Kassa and Bajgar, 1996 Tuovinen and Hanninen, 1999 Kim et al., 2002). Aerosolized scopolamine was described to protect guinea pigs against inhalation toxicity to sarin (Che et al., 2011). There are other combinations as well, such as the administration of triesterase (Tuovinen and Hanninen, 1999 Tuovinen et al., 1999), procyclidine (Kim et al., 2002 Myhrer et al., 2002, 2003), clonidine (Loke et al., 2001), or sustained release of physostigmine... 

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