Procyclidine Tranylcypromine

A hyperthermic reaction has been reported in some animals given tranylcypromine or nialamide with procyclidine or benzatropine. It was considered that this might be due to an exaggerated dopamine response. However, there do not appear to be any reports of such an interaction occurring clinically. Nevertheless, some manufacturers of irreversible non-selective MAOIs and antimuscarinics issue cautions about the possibility of increased effects of antimuscarinics when given with MAOIs. This is presumably because, in theory, inhibition of drug-metabolising enzymes by MAOIs may possibly enhance the effects of antimuscarinics. 

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