Anticonvulsants procyclidine

The action of 44 appears to be similar to that of the anticonvulsant diphenyl-hydantoin (45). Attempts have been made66) to correlate the stereochemical and biological features of 44 with those of chemically different anticonvulsants such as diphenylhydantoin, diazepam, procyclidine, trihexyphenidyl, and ethylphen-acemide. 

FIGURE 63.1. Experimental design for demonstration of anticonvulsant effects of a fixed dose of physostigmine combined with increasing doses of procyclidine relative to increasing doses of soman (A-C). Insufficient dose of procyclidine compared to soman results in early death (D). 

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