Problems, failures

The relationship of agitation problems (failure, incomplete mixing, shear energy input) with thermal runaway reactions and ways of avoiding these, are discussed. 

The hallmarks of infantile hypothyroidism (e.g., retardation of mental development and growth) become manifest only in later infancy and are largely irreversible. Consequently, early recognition and initiation of replacement therapy are crucial. In the absence of thyroid hormone therapy, the symptoms of infantile hypothyroidism include feeding problems, failure to thrive, constipation, a hoarse cry, and somnolence. In... 

Description of the logic behind all pertinent activities that occurred during scale-up, from pilot plant production to phase 3 clinical production. Discuss problems, failures, and so on. Justify the absence of equivalency concerns despite differences in process parameters, equipment, facilities, and systems. Description of the logic behind all pertinent activities that occurred during technology transfer from phase 3 clinical... 

Extent of Problem Failures due to Hydrogen-induced Cracking... 

Failure to thrive, devdppmental delay, hypotonia, neutropenia Alopecia, perioral skin erosions, hearing loss, developmental delay, hypotonia, seizures, breathing problems Failure to thrive, anorexia, developmental delay, hypotonia Failure to thrive, anorexia, developmental delay, hypotonia Failure to thrive,... 

This increase can lead to unexpected corrosion problems/failure, as well as undesirable legal ramifications. Although it is possible to eliminate stray current corrosion (Fig. 10b) with the help of proper design features, the solution is not simple. The best solution to stray current problems is electrical bonding of nearby structures, as shown in Fig. 11. Installation of additional anodes and possibly additional rectifier results in protection of both structures [38]. 

Problem Failure records at a plant indicate that a 28 watt DC solenoid that is constantly energized during normal operation of a process will almost always fail in three to five years. What needs to be added to a mechanical integrity program ... 

Secondary belite, free lime, periclase autoclave problems Failure of solid fuels (fly ash, carbonaceous shales, coal tailings as part of raw mix) to bum before granulation zone (Hawthorne, Richey, and Demoulian, 1981)... 

Tape carrier package (TCP) Tape automated bonding (TAB) package has an open circuit (98% vs. 2% misalignment problems) failure mode. 

Failure to Correct a Known Problem Failure to correct inappropriate behavior or identify risky behavior Failure to correct a safety hazard Failure to initiate corrective action Failure to report unsafe tendencies... 

Systematic failures which are not attributable to specific component failures and are therefore unique to a given system and its environment. They include design tolerance/ timing-related problems, failures due to inadequately assessed modifications and, of course, software. Failure rates cannot be ascribed to these incidents since they do not enable us to predict the performance of future designs. 

Executive or, for example, by the British Standards Institution. What this means is that in relation to that particular risk, or array of risks, the Commission has approved, with the agreement of the Secretary of State, a way of dealing with the particular problems. Failure to comply with a Code of Practice could be used as evidence that all that was reasonably practicable had not been carried out, and in that case the onus would fall on the accused to show that their measures were either as good as the Code of Practice or better. This is, of course, quite convenient and useful for large companies who are in the forefront of developments in health and safety. They can develop a system that at least does what is immediately required by the law and develop from there. But, nevertheless, there are many smaller industrial concerns which find it difficult to decide exactly what they should do, and the concept of what is reasonably practicable is not much help to them. The Health and Safety Executive produce a fair body of detailed requirements which, given some guidance, the smaller firms and less professional or less expert people will be able to follow and should keep them free from health and safety problems. 

Case 3 The product has the correct amount of preservatives but there was a failure during the cleaning steps of production and several batches were damaged. This is also a quality problem failure to maintain proper standards of cleanliness in the factory plant gave rise to a microbiological increase, causing contamination. Only the contaminated batches have to be withdrawn. 

---