Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Primidone, in serum

E7. Evenson, M. A., and Jones, P., Simultaneous measurement of diphenylhydantoin and primidone in serum by gas-liquid chromatography. Clin. Chem. 16, 107-110... [Pg.98]

Proelss and Lohmann (37) developed a rapid gas chromatograi ic screening procedure for 40 drugs, including primidone, in serum. The drugs were separated into acidic, neutral, md basic fractions by solvent extraction. The three fractions were then analysed by gas chromatography. [Pg.426]

Abraham, C. V., and Joslin, H. D. Simultaneous Gas Chromatographic Analysis for Phenobarbital, Diphenyl-hydantoin, Carbamazepine and Primidone in Serum... [Pg.1]

Determination of Phenobarbitone, Pheny-toin, Ethotoin and Primidone in Serum by Gas-Liquid Chromatography Medd. Nor. Farm, Selsk. 36(2) 78-86 (1974) CA 84 144457m... [Pg.45]

Measurement of Diphenylhydantoin and Primidone in Serum by Gas-Liquid Chromatography... [Pg.74]

Determination of Phenobarbital, Phen-ytoin, and Primidone in Serum by Gas Phase Chromatography Anal. Lett. 13(BIO) 909-919 (1980) ... [Pg.144]

Gas Chromatography-Mass Spectrometry. In serum, urine, saliva, breast-milk or tissues primidone, phenobarbitone, 4-... [Pg.922]

Anticonvulsants Phenobarbitone, phenytoin primidone, ethosuximide and carbamazepine in serum Partition ODS-SIL-X-I Water/acetonitrile (83 17)... [Pg.220]

Szabo, G.K. Browne, T.R. Improved isocratic liquid-chromatographic simultaneous measurement of phenytoin, phenobarbital, primidone, carbamazepine, ethosuximide, and N-desmethylmethsuximide in serum. Clin.Chem., 1982, 28, 100-104... [Pg.238]

Kabra, P.M. Nelson, M.A. Marton, L.J. Simultaneous very fast liquid-chromatographic analysis of ethosuximide, primidone, phenobarbital, phenytoin, and carbamazepine in serum. Clin.Chem., 1983,29, 473-476... [Pg.251]

Evenson, Jones, and Darcey (33) extracted acidified serum with chloroform, evaporated the extract, took up the residue in a chloroform solution of dehydroisoandrosterone acetate internal standard, and analyzed the solution for both primidone and dipiienyl-hydantoin by gas chromatography. The average recovery of primidone from serum was 98 percent. High grade chloroform was used to avoid extraneous peaks ... [Pg.425]

Severe osteomalacia and rickets have been seen in a few patients taking phenytoin, phenobarbital, or primidone with acetazola-mide. A marked reduction in serum primidone levels with a loss in seizure controi, rises in serum carbamazepine levels with toxicity, and rises in phenytoin levels have also been described in a veiy small number of patients given acetazolamide. [Pg.518]

A very well documented and clinically important interaction, which has been the subject of review." Reductions in serum phenytoin levels of 16 to 50% have been described in patients taking 5 to 15 mg folic acid daily for 2 to 4 weeks. If folic acid supplements are given to folate-deficient epileptics taking phenytoin, phenobarbital, primidone and possibly pheneturide, their serum antiepileptic levels should be well monitored so that suitable dosage increases can be made. [Pg.521]

An established interaction. It would be prudent to monitor phenobarbital levels in children also given carbamazepine, as changes in clearance may affect dose requirements. The small fall in serum carbamazepine levels probably has little practical importance, especially since the metabolite carbamazepine-10,11-epoxide also has anticonvulsant activity. Consider also Carbamazepine + Primidone , below. [Pg.534]

Minor to modest falls in serum ethosuximide levels may occur if carbamazepine, primidone or phenytoin are also given, whereas methylphenobarbital or sodium valproate may cause a rise in ethosuximide levels. The effect of all these changes on seizure control is uncertain. Lamotrigine appears not to affect ethosuximide levels. [Pg.539]

Furthermore, evidence from clinical studies suggests that levetiraeetam does not affect the serum levels of gabapentin, lamotrigine, phenobarbital, or primidone. In general therefore, no dosage adjustments would seem to be needed if levetiraeetam is used as add-on therapy with any of these drugs. [Pg.544]

Valproate has been reported to cause increases, decreases, and no change in serum primidone levels. Primidone-derived phenobarbital levels appear to be increased by valproate. [Pg.571]

In one study the ratio of plasma level to dose of zonisamide was 29% lower in 11 patients also taking phenobarbital than in 28 patients taking zonisamide alone, suggesting that phenobarbital reduces zonisamide levels. Similarly, another study in healthy subjects found that pretreatment with phenobarbital increased the clearance of a single dose of zonisamide by about twofold. A further study found no changes in the serum levels of phenobarbital or primidone in 34 and 13 patients, respectively, who were also given zonisamide. ... [Pg.580]

The use of benzodiazepines with antiepileptics is common and possibly accompanied by some changes in serum levels, which are normally of limited clinical importance. However, isolated interactions have been reported between chlordiazepoxide or cloba-zam and phenobarbital between clonazepam and lamotrigine or primidone and between clorazepate and primidone. [Pg.718]

Gas Chromatographic Method for the Simultaneous Determination of Pheno-barbitone. Primidone, and Phenytoin in Serum Using a Nitrogen Detector... [Pg.96]

A Gas Chromatographic Method for the Dermination of Carbamazepine, Phenobarbital, Phenytoin and Primidone in the Same Extract of Serum... [Pg.142]

Kabra PM, Stafford BE, Marton LJ (1977) Simultaneous measurement of phenobarbi-tal, phenytoin, primidone, ethosuximide and carbamazepine in serum by high-pressure liquid chromatography. Clin Chem 23 1284-1288... [Pg.210]

When carbamazepine is administered with primidone, decreased primidone levels and higher carbamazepine serum levels may result. Cimetidine administered with carbamazepine may result in an increase in plasma levels of carbamazepine that can lead to toxicity. Blood levels of lamotrigine increase when the agent is administered with valproic acid, requiring a lower dosage of lamotrigine... [Pg.258]

The major untoward effect of phenobarbital and primidone, when used as anticonvulsants, is sedation. Another side effect of considerable importance, particularly in children, is a possible disturbance in cognitive function. Even when the serum concentration is within the therapeutic range, apparently the ability to concentrate and perform simple tasks is decreased. [Pg.381]

See other pages where Primidone, in serum is mentioned: [Pg.220]    [Pg.13]    [Pg.25]    [Pg.1139]    [Pg.1222]    [Pg.46]    [Pg.521]    [Pg.534]    [Pg.570]    [Pg.25]    [Pg.1139]    [Pg.1222]    [Pg.291]    [Pg.339]    [Pg.118]    [Pg.380]    [Pg.1402]    [Pg.118]    [Pg.580]    [Pg.1583]   
See also in sourсe #XX -- [ Pg.13 ]



SEARCH



In serum

Primidon

© 2024 chempedia.info