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Primidon

Primidone [125-33-7] C22H24N2O2 (39) is an analogue of phenobarbital that is used for the treatment of generalized tonic-clonic seizures. It is metabolized in humans to phenobarbital (6) and phenylethyLmalondiamide [7206-76-0J, C22H24N2O2 (40) and these metaboUtes are probably responsible for its anticonvulsant actions. Primidone has many of the side effect HabiUties seen with phenobarbital. [Pg.535]

These have generally been replaced in veterinary medicine by inhalation anesthetics. Phenobarbital /T(9-(9G, phenytan [57-41-0], and primidone [125-33-7] are used as anticonvulsants. [Pg.405]

The anticonvulsant primidone (1035) resembles phenobarbital but lacks the 2-oxo substituent. It was introduced in 1952 and has remained a valuable drug for controlling grand mal and psychomotor epilepsy. As might be expected, primidone is metabolized to yield phenobarbital (1034 X = 0) and C-ethyl-C-phenylmalondiamide (1036), both of which have marked anticonvulsant properties however, primidone does have intrinsic activity and an appropriate mixture of its metabolites has only a fraction of its activity (73MI21303). Primidone may be made in several ways, of which desulfurization by Raney nickel of the 2-thiobarbiturate (1034 X = S) or treatment of the diamide (1036) with formic acid (at 190 °C) seem to be the most satisfactory (54JCS3263). [Pg.153]

Detection and result The chromatogram was freed from mobile phase (first dried for 5 min in a stream of cold air, then heated for 10 min at 110°C and allowed to cool), immersed for 5 s in the reagent solution and finally heated for 2 min at 110°C. Grey to grey-blue zones were formed on a light background. The following hRf values were obtained primidone QiR( 10-15) carbamazepine hRf 40 — 45) phenytoin hR( 50 — 55) phenobarbital hRf 60) ethosuximide hRf 75) hexobarbital hRf 90 — 95). [Pg.254]

Fig. 1 Reflectance scan of a blank (A) and of a mixture of antiepileptics with 500 ng substance per chromatogram zone (B). Start (1), primidone (2), carbamazepine (3), phenytoin (4), phenobarbital (5), ethosuximide (6), hexobarbital (7) and solvent front (8). Fig. 1 Reflectance scan of a blank (A) and of a mixture of antiepileptics with 500 ng substance per chromatogram zone (B). Start (1), primidone (2), carbamazepine (3), phenytoin (4), phenobarbital (5), ethosuximide (6), hexobarbital (7) and solvent front (8).
Prilocaine 1, 17 Primaquine 1, 346 Primidolol 29 Primidone j, 276 Prizidilol 151 Probarbital 268... [Pg.275]

Fluoro uracil mercury Tegafur Formaldehyde Biperiden Bronopol Cortivazol Edetate disodium Glaziovine Hexetidine Meptazinol Metampicillin sodium Methylol riboflavin Nifurfoline Nifurtoinol Noxytiolin Oxymetazoline HCI Phenindamine tartrate Pipebuzone Thihexinol Timonacic sodium Triclobisonium chloride T romethamine Tyloxapol Formamide Cimetide Primidone Protriptyline Razo xane Spiperone Formic acid Bupivacaine... [Pg.1635]

When the hydantoins are administered with the suc-cinimides there may be an increase in the hydantoin blood levels. Concurrent administration of valproic acid and the succinimides may result in either a decrease or an increase in succinimide blood levels. When primidone in administered with the succinimides, lower primidone levels may occur. [Pg.258]

When carbamazepine is administered with primidone, decreased primidone levels and higher carbamazepine serum levels may result. Cimetidine administered with carbamazepine may result in an increase in plasma levels of carbamazepine that can lead to toxicity. Blood levels of lamotrigine increase when the agent is administered with valproic acid, requiring a lower dosage of lamotrigine... [Pg.258]

There is an increased risk of cyclosporine toxicity when the drug is administered with acetazolamide. Decreased serum and urine concentrations of primidone occur when the drug is administered with acetazolamide. [Pg.448]

QH12N2 19275-55-9) see Etodolac ethylphenylmalondiamide (C11H14N2O2 7206-76-0) see Primidone ethylphenylmalonic acid diethyl ester see under diethyl cthylphenylmalonate... [Pg.2384]

CH3NO 75-12-7) see Allopurinol Chlorothiazide Cimetidine Fludarabinc phosphate Fluspirilene Heptaminol Primidone Protriptyline Pyridoxine Razoxane Sulfadoxine Theophylline... [Pg.2389]

Primidone GM/PE Works partly by conversion to phenobarbitone in body... [Pg.345]


See other pages where Primidon is mentioned: [Pg.811]    [Pg.327]    [Pg.749]    [Pg.303]    [Pg.337]    [Pg.340]    [Pg.364]    [Pg.436]    [Pg.1295]    [Pg.1295]    [Pg.1295]    [Pg.1688]    [Pg.1713]    [Pg.1715]    [Pg.1718]    [Pg.1720]    [Pg.1720]    [Pg.1720]    [Pg.1732]    [Pg.1732]    [Pg.1734]    [Pg.1736]    [Pg.1741]    [Pg.257]    [Pg.1709]    [Pg.1709]    [Pg.179]    [Pg.191]    [Pg.239]    [Pg.654]    [Pg.671]   
See also in sourсe #XX -- [ Pg.126 , Pg.404 ]




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Acetazolamide Primidone

Anticonvulsant agents primidone

Antiepileptic drugs primidone

Children primidone

Chlortetracycline Primidone

Cisplatin Primidone

Clonazepam Primidone

Clorazepate Primidone

Dexamethasone Primidone

Disulfiram Primidone

Dizziness primidone

Doxycycline Primidone

Drowsiness primidone

Ethosuximide Primidone

Felbamate Primidone

Fentanyl Primidone

Folic acid Primidone

Hormonal) Primidone

Infants primidone

Isoniazid Primidone

Lamotrigine Primidone

Levetiracetam Primidone

Mesuximide Primidone

Methadone Primidone

Methylphenidate Primidone

Mysoline - Primidone

Neonates primidone

Nicotinamide Primidone

Oxytetracycline Primidone

Pharmacology primidone

Phenobarbital primidone and

Piracetam Primidone

Pregnancy primidone

Primidone

Primidone Acetaminophen

Primidone Alcohol

Primidone Benzodiazepines

Primidone Carbamazepine

Primidone Contraceptives, hormonal

Primidone Coumarins

Primidone Cyclosporine

Primidone Diphenylhydantoin

Primidone Ethanol

Primidone Fosphenytoin

Primidone Niacinamide

Primidone Phenytoin

Primidone Quinidine

Primidone Ritonavir

Primidone Sodium valproate

Primidone Tetracycline

Primidone Tiagabine

Primidone Topiramate

Primidone Valproate

Primidone Vigabatrin

Primidone Zonisamide

Primidone adverse effects

Primidone and carbamazepine

Primidone anticonvulsant

Primidone chemical structure

Primidone dosing

Primidone drug interactions

Primidone indications

Primidone interaction

Primidone metabolism

Primidone pharmacokinetics

Primidone side effects

Primidone therapeutic range

Primidone therapeutic risks

Primidone, estimation

Primidone, in serum

Prysoline - Primidone

Renal effects primidone

Seizures primidone

Sertan - Primidone

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