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Diphenyl hydantoin

V-Subslilulion and 5,5-disubstitution prevent ring opening as demonstrated by various examples. Ethotoin (3-ethyl-5-phenylhydantoin, 4.230), in contrast to its /V-dcclhylalcd metabolite, was not detectably hydrolyzed by DHPase. No ring-opened metabolite was found for phenytoin (5,5-diphenyl-hydantoin, 4.231) or nirvanol (5-ethyl-5-phenylhydantoin, 4.232), which is the AT-demethylated metabolite of mephenytoin (4.233) [144],... [Pg.157]

DIPHENTOIN DIPHENYLAN SODIUM DIPHENYLHYDANTOIN SODIUM 5,5-DIPHENYL-HYDANTOIN SODIUM 5,5-DIPHENYL-2,4-IMIDAZOLIDINE-DIONE, MONOSODIUM SALT DI-PHETINE DITOIN DIVULSAN DPH ENKEFAL... [Pg.515]

Arene oxide 80 has been reported as a stable metabolite of 5,5-diphenyl-hydantoin. Since no substituted benzene oxides have previously been isolated as metabolites and since an oxirane hemiacetal structure would be predicted to be highly unstable, the structural assignment in this report is highly questionable. [Pg.212]

Chow, A.H.L. Gordon, J.D. Szeitz, A. Young, J.W.M. Modification of phenytoin crystals. III. Influence of 3-butanoylox5miethyl-5,5-diphenyl-hydantoin on solution-phase crystallization and related crystal properties. Int. J. Pharm. 1995, 126, 11-19. [Pg.46]

Wallace, J E. Microdetermination of diphenyl hydantoin in biological specimens by ultraviolet spectrometry Anal. Chem (1968), 978 - 980 ... [Pg.149]

A. J. Wilensky and J. A. Lowden, Inadequate serum levels after intramuscular administration of diphenyl-hydantoin, Neurology, 23, 318-324 (1973). [Pg.144]

W4. Wallace, J. E., Simultaneous spectrophotometric determination of diphenyl-hydantoin and phenobarbital in biologic specimens. Clin. Chem. 15, 323-330 (1969). [Pg.108]

It is structurally and chemically related to tricyclic antidepressant drug imipramine and pharmacologically it is similar to diphenyl hydantoin sodium. It is effective in grandmal and psychomotor epilepsy and also in the treatment of trigeminal neuralgia (a condition characterized by paroxysms of intense pain of stabbing nature within the area of distribution of trigeminal nerve without sensory loss). [Pg.107]

The action of 44 appears to be similar to that of the anticonvulsant diphenyl-hydantoin (45). Attempts have been made66) to correlate the stereochemical and biological features of 44 with those of chemically different anticonvulsants such as diphenylhydantoin, diazepam, procyclidine, trihexyphenidyl, and ethylphen-acemide. [Pg.24]

Fig. 2.4. Flowdiagram of the procedure for extraction of phenobarbital, primidone and diphenyl-hydantoin from serum. Fig. 2.4. Flowdiagram of the procedure for extraction of phenobarbital, primidone and diphenyl-hydantoin from serum.
SODIUM DIPHENYL HYDANTOINATE SODIUM-5,5-DIPHENYLHYDANTOINATE SODIUM-5,5-DIPHENYL-2.4-IMIDAZOLIDINEDIONE SOLANTOIN... [Pg.515]

Seeman P, Chau-Wong M, Moyyen S (1972) The membrane binding of morphine, diphenyl-hydantoin, and tetrahydrocannabinol. Can J Physiol Pharmacol 50 1193-1200... [Pg.77]

Painter MJ, Pippenger C, MacDonald H, et al. Phenobarbital and diphenyl-hydantoin levels in neonates with seizures. J Pediatr 1978 92 315-319. [Pg.99]

BXSB/Mp, NZBxNZW/Fl, NZM, AKR). Experience with any of these strains is scarce and is restricted mainly to salts of heavy metals such as mercury. Mercury has been clearly shown to have immunostimulatory effects in NZBxNZW/Fl mice (Pollard et al., 1999). In a study examining the immunotoxic effects of diphenyl-hydantoin (Bloksma et al., 1994), MRL mice were exposed to the drug in the drinking-water for a period of six months in this case, however, no indications of adverse immune reactions were found. Future studies should include more autoimmunogenic pharmaceuticals and negative controls in order to determine the extent to which systemic lupus erythematosus-prone models are useful to study or predict chemical-induced autoimmunity. [Pg.187]

An equimolar mixture of phenyl isocyanate and dimethylformamide diethyl acetal heated several hrs. at 100-130 4-dimethylamino-4-ethoxy-l,3-diphenyl-hydantoin. Y 80-85%. F. e. s. H. Bredereck, G. Simehen, and E. Goknel, Ang. Gh. 76, 861 (1964). [Pg.198]

Analysis of Phenobarbital, Diphenyl-hydantoin, Carbazepine and Primidone in Blood... [Pg.1]

Abraham, C. V., and Joslin, H. D. Simultaneous Gas Chromatographic Analysis for Phenobarbital, Diphenyl-hydantoin, Carbamazepine and Primidone in Serum... [Pg.1]

Quantitative Estimation of Diphenyl-hydantoin. Primidone, and Fheno-barbital in Plasma by Gas-Liquid Chromatography... [Pg.145]

A Practical Routine Gas Chromatographic Determination of Pheno-babrbital. Primidone, and Diphenyl-hydantoin... [Pg.164]

The Enzymic-Immunologic Method in Clinical and Forensic Toxicology. Comparative Analysis in Diphenyl-hydantoin Assays Carried Out with EMIT [Enzyme-Multiplied Immunoassay Technique] and Gas Chromatography... [Pg.166]

Correlation of the E.M.I. Diphenyl-hydantoin Assay in Blood Plasma with G.L.C. and a Spectrophoto-metric Method... [Pg.240]

S., Kubo, S., and Iwai, H. Comparison of Homogeneous Enzyme Immunoassay (EMIT) and Gas-Liquid Chromatographic Measurements of Plasma Phenobarbital, Diphenyl-hydantoin and Primidone Concentrations in Epileptic Patients Kawasaki Med. J. 3(l) 59-66 (1977) CA 87 126838u... [Pg.271]

See other pages where Diphenyl hydantoin is mentioned: [Pg.208]    [Pg.919]    [Pg.97]    [Pg.919]    [Pg.230]    [Pg.1162]    [Pg.239]    [Pg.332]    [Pg.212]    [Pg.44]    [Pg.2552]    [Pg.217]    [Pg.2]    [Pg.208]    [Pg.919]    [Pg.97]    [Pg.919]    [Pg.230]    [Pg.583]    [Pg.1882]    [Pg.42]    [Pg.62]    [Pg.323]    [Pg.1162]    [Pg.2]    [Pg.2]    [Pg.239]    [Pg.332]    [Pg.62]    [Pg.212]    [Pg.299]    [Pg.44]    [Pg.313]    [Pg.2552]    [Pg.600]    [Pg.217]   
See also in sourсe #XX -- [ Pg.915 ]

See also in sourсe #XX -- [ Pg.915 ]

See also in sourсe #XX -- [ Pg.212 ]



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5, 5-Diphenyl hydantoin sodium

Hydantoin

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