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Primidone Methadone

BARBITURATES ANALGESICS - OPIOIDS 1. Barbiturates t sedative effects of opioids 2.1 efficacy of fentanyl and methadone with phenobarbital and primidone 1. Additive sedative effect. 2. t hepatic metabolism of fentanyl and methadone 1. Monitor respiratory rate and conscious levels 2. Be aware that the dose of fentanyl and methadone may need to t... [Pg.212]

OPIOIDS ANTIEPILEPTICS 1. Barbiturates T sedative effects of opioids 2.1 efficacy of fentanyl and methadone with carbamazepine, phenobarbital, phenytoin or primidone 3. Carbamazepine l tramadol levels 4. Risk of pethidine toxicity 1. Additive sedative effect 2. t hepatic metabolism of fentanyl and methadone, and possibly an effect at the opioid receptor 3. Carbamazepine T metabolism of tramadol 4. Phenytoin induces metabolism of pethidine, which causes T level of a neurotoxic metabolite 1. Monitor respiratoiy rate and conscious levels 2. Be aware that the dose of fentanyl and methadone may need to be t 3. Watch for poor effect of tramadol. Consider using an alternative opioid 4. Co administer with caution the effect may be i by administering pethidine intravenously... [Pg.475]

Noninterfering acetaminophen, aspirin, amitriptyline, huprenorphine, caffeine, carba-mazepine, chlorpromazine, desipramine, dextromethorphan, doxepin, ephedrine, fenfluramine, imipramine, lidocaine, loxapine, meperidine, methadone, methaqualone, naloxone, naltrexone, nicotine, orphenadrine, oxycodone, papaverine, pentazocine, phendimetra-zine, phenmetrazine, phentermine, phenylpropanolamine, phenytoin, primidone, procaine, promethazine, propoxyphene, propyphenazone, theobromine, theophylline, trazodone, triflupromazine, trimethoprim, trimipramine... [Pg.432]

Information is limited but the interaction between methadone and these enzyme-inducing antiepileptics appears to be established and of clinical importance. Anticipate the need to increase the methadone dosage in patients taking carbamazepine, phenytoin or phenobarbital. It may be necessary to give the methadone twice daily to prevent withdrawal symptoms appearing towards the end of the day. It seems probable that primidone will interact similarly because it is metabolised to phenobarbital. Also be aware of the need to reduce the methadone dose if any enzyme-inducing antiepileptic is stopped. Valproate appears not to interact. [Pg.163]

See other pages where Primidone Methadone is mentioned: [Pg.610]    [Pg.193]    [Pg.62]    [Pg.80]    [Pg.157]    [Pg.174]    [Pg.209]    [Pg.248]    [Pg.393]    [Pg.426]    [Pg.444]    [Pg.481]    [Pg.497]    [Pg.527]    [Pg.564]    [Pg.647]    [Pg.663]    [Pg.691]    [Pg.702]    [Pg.729]    [Pg.761]    [Pg.816]    [Pg.856]    [Pg.871]    [Pg.881]    [Pg.904]    [Pg.947]    [Pg.1023]    [Pg.1069]    [Pg.1110]    [Pg.1198]    [Pg.1220]    [Pg.1298]    [Pg.1365]    [Pg.1392]    [Pg.1424]    [Pg.1453]    [Pg.1476]    [Pg.62]    [Pg.80]    [Pg.157]    [Pg.174]    [Pg.209]   
See also in sourсe #XX -- [ Pg.163 ]



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