Primidone Ethanol

Noninterfering acetaminophen, acetylmorphine, amiodarone, amobarbital, amphetamine, bendroflumethiazide, benzocaine, benzoylecgonine, benzthiazide, butalbital, carbamaze-pine, chlorothiazide, clonazepam, cocaine, codeine, cotinine, cyclosporine, cyclothiazide, desalkylflurazepam, diamorphine, dicumerol, ephedrine, ethaciynic acid, ethanol, eth-chlorvynol, ethosuximide, furosemide, glutethimide, hydrochlorothiazide, hydrocodone, hydroflumethiazide, hydromorphone, lorazepam, mephentermine, meprobamate, meth-amphetamine, metharbital, methoxsalen, methoxyphenteramine, methsuximide, meth-ylcyclothiazide, metoprolol, MHPG, monoacetylmorphine, morphine, normethsuximide, oxazepam, oxycodone, oxymorphone, pentobarbital, phencyclidine, phenteramine, phenylephrine, phenytoin, polythiazide, primidone, prochlorperazine, salicylic acid, sulfanilamide, THC-COOH, theophylline, thiazolam, thiopental, thioridazine, tocainide, trichlo-romethiazide, trifluoperazine, valproic acid, warfarin... 

X-ray powder diffraction patterns (7,8) and infrared spectra (see Section 2,1) indicate that primidone may crystallize in at least two different forms. One of these (here designated Form I) usually crystallizes when a solution of primidone in 95 percent ethanol is evaporated at room temperature. The second (here designated Form II) usually forms if primidone... 

Pippenger and Gillen (32) determined primidone, phenobarbital, phenylethylmalondiamide, and a number of other amticonvulsants in plasma, urine, and cerebrospinal fluid. They extracted the sample with chloroform after buffering to pH 6.8. The chloroform extract was evaporated to dryness and the residue dissolved in a small amount of absolute ethanol for injection. Recoveries of known amounts of drugs added to the body fluids were 90 to 100 percent. 

Detection was by spraying with mercuric chloride and eosin in 95 percent ethanol. The minimum detectable amount of primidone was 50 Mg. 

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