Pre-organisation

A pre-organisation period (in which the first replicating systems evolved) and The maturation period (in which the first bacterium evolved from the first replication system). 

This selectivity can be attributed to the presence of the templating agent which, by hydrogen bonding, pre-organises the olefins before irradiation. 

One of the more interesting hole size effects arises when the metal ion successfully acts as a template, but is labilised in the macrocyclic complex that is formed. The consequence of this is that the metal ion acts as a transient template. The metal ion may be viewed as pre-organising the reactants to form the macrocyclic products, but then finding itself in an unfavourable environment after the cyclisation. The effect is best observed when a small metal ion is used as a template for a reaction that can only give one product (or at least, only one likely product). What happens to the metal ion when it finds itself in an environment that does not match up to its co-ordination requirements The most useful consequence would be labilisation of the metal ion, with resultant demetallation and formation of the metal-free macrocycle. This would overcome one of the major disad-... 

The incorporation of the 3 -endo locked (4, 2 ) dU analogue (45) in TFOs enhanced thermal stability, and confirms that the correct conformational pre-organisation of a TFO favours its interaction with a duplex. The introduction of a 2 -0-methyl group into LNA (46) has the opposite effect to DNA, in that the LNA derivative is considerably destabilised." ... 

Noncentrosymmetric pre-organisation of NLO chromophore was mainly achieved using organic dipolar compounds, and supermolecules... 

On the other hand, Miller177 proposed a pre-organisation model in which the reactant molecule is adsorbed in the zeolite channel in a cyclic conformation similar to a transition state this reduces the entropy of activation and favours 1-6 closure. 

Whitcombe described a hybrid method of imprinting where a covalent bond conformationally limited the template prior to a non-covalent type pre-organisation and subsequent polymerisation [136], It was claimed that this type of approach reduced heterogeneity in the binding site population. 

Moller. K. Bein. T. Inclusion chemistry in periodic niesoporous hosts. Chem. Mater. 1998. 10. 2950-2963. Okazaki, T. Suenaga. K. Hirahara. K. Banow. S. lijima, S. Shinohara. H. Real time reaction dynamics in carbon nano-tubes. J. Am. Chem. Soc. 2001. 123. 9673-9674. Sun, D. Reed. C.A. Crystal engineering a linear polymer of Cgo fullerene via supramolecular pre-organisation. Chem. Commun. 2000, 2391-2392. 

Klein Gebbink, R.J.M. Martens. C.F. Feiters, M.C. Nolte, R.J.M. Novel molecular receptors capable of forming CU2-O2 complexes. Effect of pre-organisation on O2 binding. Chem. Commun. 1997. (4), 389. 

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