Progesterone Receptor PR

ER Estrogen Receptor, AR Androgen Receptor, GR Glucocorticoid Receptor, TR Thyroid Receptor, RAR Retinoic Acid Receptor, RXR Retinoie X Receptor, PR Progesterone Receptor, VDR Vitamin D Receptor, PPAR Peroxisome Proliferator-Activated Receptor, PXR Pregnane X Receptor, ROR Retinoic Acid-Related Orphan Receptor, NHF-4 Hepatocyte Nuclear Eactor 4, ERR Estrogen-Related Receptor... 

TTF-1, thyroid transcription factor-1 CK, cytokeratin ER, estrogen receptor, PR, progesterone receptor PSA, prostate-specific antigen PAP, prostatic acid phosphatase. 

CIST, gastrointestinal stromal tumor IMT, Inflammatory myofibroblastic tumor N, negative PR, progesterone receptor S, sometimes positive SFT, solitary fibrous tumor SMA, smooth muscle actin SS, stromal sarcoma +, almost always positive. 

El -Oestradiol ER - Oestrogeit receptor PR - Progesterone receptor Fig. 3 Progesterone receptor synthesis is dependent on the integrity of the oestrogen receptor pathway. 

Figure 16.7 Immunohistochemical staining intensity as a function of the duration of formahn fixation. Immunostaining intensity was measured in triphcate.The coefficients of variation (CVs) were almost aU less than 10% and, for purposes of clarity, are not shown. Staining intensity is measured as mean pixel intensity units on a 1-256 scale. ER(1D5), ER(2-123), PR(636), PR(1294), and Ki-67(MIB-1), DakoCytomation, Carpinteria, CA PR(1A6) and HER2(CB11), Vision Biosystems, NorweU, MA. ER, estrogen receptor PR, progesterone receptor. Reproduced with permission from Reference 15, 2006 American Society for Clinical Pathology.

Selective progesterone receptor modulators (SPRMs, mesoprogestins) are progesterone receptor (PR) ligands... 

Sex steroid receptors are members of the steroid hormone receptor (SHR) family that ligand-dependently regulate functions of the sexual organs. Sex steroid receptors are the androgen receptor [1] (AR), the estrogen receptor a [2] and (3 [3] (ERa, ER 3), and the progesterone receptor [4] (PR). 

Sex Steroid Receptors Androgen Receptor, Estrogen Receptors, Progesterone Receptor. Figure 1 Schematic structures of AR, ERa, ER(3, and PR. 

Hormone-receptor status. Patients with negative-estrogen-receptor (ER) and negative-progesterone-receptor (PR) tumors have a worse prognosis. 

As mentioned above, our studies and other articles demonstrate substantially complete restoration of immunoreactivity (AR rate = 100%) for many antigens (proteins) exemplified by ER, progesterone receptor (PR), HER2/neu,... 

Figure 7.5 Stability of peptide controls, for HER-2 (top panel), progesterone receptor (PR) 636 monoclonal antibody (middle panel), and estrogen receptor (ER) 1D5 monoclonal antibody (bottom panel). The dotted line represents the immunoreactivity of peptide controls stored at room temperature. The slight dip in immunoreactivity at the 3-month time interval is related to a slight inconsistency in the staining protocol (immu-nohistochemical detection) rather than an actual decrease in stability. Each time point is the mean + SD of four replicate peptide controls. Copied with permission from Bogen et al.9...

The interaction of CSN5 to the member of the IkB multigene family Bcl3, the progesterone receptor PR, and the steroid receptor co-activator SRC-1, leads to stabilization of Bcl3-p50 and PR-SRC-1 complexes and enhances transcriptional activity [42, 43]. Whereas AP-1 activity is stimulated by interaction of CSN5 with the integrin adhesion receptor LFA-1 [44], the opposite effect was reported in the... 

The physiological effects of progesterone are mediated by two progesterone receptor isoforms termed PR-A and PR-E. These arise from a single gene and act as ligand-activated transcription factors to regulate the expression of... 

Sexual receptivity. The effects of THC on sexual behavior in female rats and its influence on steroid hormone receptors and neurotransmitters in the facilitation of sexual receptivity was examined. Results revealed that the facilitatory effect of THC was inhibited by antagonists to both progesterone and dopamine D(l) receptors. To test further the idea that progesterone receptors (PR) and/or dopamine receptors (D[1]R) in the hypothalamus were required for THC-facilitated sexual behavior in rodents, antisense, and sense oligonucleotides to PR and D(1)R were administered intra-cerebroventricularly into the third cerebral ventricle of ovariectomized, estradiol benzoate-primed rats. Progesterone- and THC-facilitated sexual behavior was inhibited in animals treated with antisense oligonucleotides to PR or to D(1)R. Antagonists to... 

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