Powder supercritical fluid technology

York, P. and Hanna, M. (1996). Particle engineering by supercritical fluid technologies for powder inhalation drug delivery. Proc. Conf. Respiratory Drug Delivery V, Phoenix, AZ, 231-239. 

Rehman, M., Shekunov, B. Y., York, P, et al. Optimisation of powders for pulmonary delivery using supercritical fluid technology, Eur. J. Pharm. Sci., 22,1-17. 

Tservistas, M. Levy, M.S. Lo-Yim, N.Y.A. O Kennedy, R.D. York, R Humphreys, G.O. Hoare, M. The formation of plasmid DNA-loaded pharmaceutical powders using supercritical fluid technology. Biotech. Bioeng. 2001, 71, 12-18. Bodmeier, R. Chen, H. Indomethacin polymeric nanosuspensions prepared by microfluidization. J. Controlled Release 1990, 12, 223-233. 

Shekunov, B. Powders for respiratory drug dehvery. In Supercritical Fluid Technology for Drug Product Development, York, P., Kompella, U.B., Shekunov, B., Eds. Marcel Dekker, Inc. New York, 2004 Vol. 138, 247-282. 

Jovanovic, N., Bouchard, A., Holland, G. W, Witkamp, G., and Crommehn, Jiskoot, W. (2004) Stabihzation of proteins in dry powder formulation using supercritical fluid technology. Pharm. Res. 21, 1955-1969. 

Jovanovic N, Bouchard A, Holland GW, Witkamp GJ, Crommelin DJA, and Jiskoot W. Stabilization of Proteins in Dry Powder Formulations Using Supercritical Fluid Technology. Pharm Res 2004 21 1955-1969. 

Shekunov BY. Production of powders for respiratory drug delivery. In York P, Kompella UB, Shekunov BY, eds. Supercritical Fluid Technology for Drug Product Development. New York Marcel Dekkar, 2004 247-282. 

Shekunov BY, Rehman M, Chow AHL, Tong HHY, York P. Production of crystalline powders for inhalation drug delivery using supercritical fluid technology. Proceedings of the 6th International Symposium on Supercritical Fluids, April 28-30, 2003, Versailles, France. 

Bustami RT, Chan HK, Foster NR. Aerosol delivery of protein powders processed by supercritical fluid technology. Proceedings of the Conference on Respiratory Drug Delivery VII, Palm Harbor, FL, 2000 611-613. 

Tservistas M, Levy MS, Lo-Yim MYA, O Kennedy RD, York P, Humphreys GO, Hoare M. The formation of plasmid DNA loaded pharmaceutical powders using supercritical fluid technology. Biotechnol Bioeng 2001 72 12-18. 

Kompella UB, Koushik K. Preparation of drug delivery systems using supercritical fluid technology. Crit Rev Ther Drug Carrier Syst 2001 18 173-199. Petersen RC, Matson DW, Smith RD. Precipitation of polymeric materials from supercritical fluid solution the formation of thin films, powders, and fibers. Polym Prepr (Am Chem Soc, Div Pol Chem) 1986 27 261-262. 

Varshosaz J, Hassanzedh F, Mahmoudzadeh M, Sadeghi A (2009) Preparation of cefuroxime axetil nanoparticles by rapid expansion of supercritical fluid technology. Powder Technol 189(1) ... 

Supercritical fluids (scf) are highly compressed liquids or gases. The latter already have an established role in "clean extraction (substitution of chlorinated/organic solvents) on an industrial scale (e. g. decaffeination of coffee and tea, extraction of hops, spices, etc.). The specific physical and chemical properties of scf make them particularly suitable for a variety of other applications, e. g. reactions, powder technology and impregnation. 

The use of supercritical fluid processing technology has also been widely used for its application in controlled microparticle formation. Conventional small molecules and proteins for inhalation have been generated and formulated as powders for inhalation. [183-186],... 

Developing particles for inhalation with its recently acquired Bradford Particle Technology, UK, a pioneer in the use of supercritical fluids for processing drug powders. 

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