Lysine potential drug target

Albmnin is one of the soluble macromolecular carriers available for drug targeting purposes. With a molecular weight of approximately 67 kDa, it is small in size as compared to other potential carriers. It can be derivatized with molecules that will determine its cell specificity, and with drug molecules. A maximum of about 60 molecules can be coupled to albumin through the e-NHj of the lysine residues. Table 4.1 shows the modified albmnins that have been used for targeting to SECs and KCs. 

Ryser, J.-R and Shen, W.-C., Drug-poly(lysine) conjugates their potential for chemotherapy and for the study of endocytosis, in Targeting of Drugs with Synthetic Systems, Gregoriadis, G., Senior, J., and Poste, G., Eds., Plenum Press, New York, p. 103,1986. 

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