Potential Targets of Drug Action

In contrast to drugs acting from the outside on cell membrane constituents, agents acting in the cell s interior need to penetrate the cell membrane. 

The hydrophobic interior of the phospholipid membrane constitutes a diffusion barrier virtually impermeable to charged particles. Apolar particles, however, are better able to penetrate the membrane. This is of major importance with respect to the absorption, distribution, and elimination of drugs. 

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