Possible binding sites

Now, most metal ion/organic molecule chemical reactions inside cells also come to equilibrium rapidly. The organic products, made irreversibly available by synthesis under feedback control, contain a broad set of possible binding sites for selected metal ions mainly in soluble proteins (enzymes) and in the pumps for uptake or rejection managed at the cell membrane, as well as in the factors, transcription factors, necessary for controlled production of those organic products under the direction of the coded system. These ion-selective binding sites are common to all cells so that while all cells are based on similar major organic reactions and similar but specific biopolymer products, they also have in common a set of... 

Histidine residues are, however, generally regarded as major possible binding sites for ruthenium-arene complexes in proteins. To model this interaction, we also studied the reaction of [RuCl(en)(rj6-bip)]+ (10) with L-histidine at 310 K in aqueous solution (91). The reaction was quite sluggish and did not reach equilibrium until 24 h at 310 K, by which time only about 22% of the complex had reacted. Two isomeric imidazole-bound histidine adducts could be discerned, with more or less equal binding of Ne... 

Actin molecules possess four possible binding sites two binding sites for adjacent molecules to form strands (intrastrand binding) and two sites for binding of actin molecules in neighbouring strands (inter strand binding). 

Despite a preselection procedure, aptamers may be selected that bind to the bare selection matrix, the cellulose filter, or any other component of the selection setup, because the possible binding sites are presented in a large number (compared to... 

Efficient self-assembly occurs when there is a match between the geometric or stereochemical preferences of the components, e.g. the coordination polyhedron of a metal ion and the possible binding site arrangement(s) on a ligand. These pairings are sometimes referred to as incommensurate symmetry interactions or interactional algorithms... 

Use functional annotation databases to provide insights into the putative functions of the selected genes and gene families and analyze the target structures for possible binding sites, active sites, and other functionally important domains. 

The seven helical spans through the membrane are indicated. Furthermore, Figure 8 provides three additional relevant facts or suggestions. The first one deals with the possible binding site of azido-... 

The essential thiol (Cys-149) initiates a short helical region in which the nonreactive Cys-153 occurs after one turn so that it comes close to Cys-149 (cf. Section II,B,4,a). The polypeptide chain then returns to the vicinity of the active center as part of an antiparallel sheet that contains His-176. There follows an S-shaped antiparallel sheet (residues 179-200) that interacts with NAD+ in the R-axis-related subunit. This segment of the chain also contains Lys-191 which has been implicated as a possible binding site for phosphate. Histidine-176, conserved in all species (55, 57), occurs within hydrogen bonding distance of Cys-149, and these two residues are clearly implicated in the catalytic mechanism (see Section II,B,4,d). 

Kinetic analysis demonstrated that (+)-calanolide A inhibited HIV-1 RT by a complex mechanism involving two possible binding sites one of the calanolide binding sites is near both the pyrophosphate binding site and the active site of the RT enzyme. ... 

Single-stranded regions of nucleic acids provide metal ions with access to all possible binding sites in the nucleotide residues. In contrast, nncleic acid tertiary stmcture, while creating some restrictions on metal binding in certain regions, may also provide other sites at which donor atoms located... 

Therefore, structure II was modified by varying substituents and substitution patterns on the aromatic ring, and by varying alkyl substituents on the amino groups. Chains were also extended to search for other possible binding sites. 

This illustrates that for an ion in exchange with a binding site where rc is expected to be long, T2F < T2s- From equation (76) it is clear that as the concentration of possible binding sites, [5,], rises, so the measured rate of relaxation rises. [5,] is obviously proportional to the number of binding sites per molecule ( ), and may be written as [S,] = , [C], where [C] is the concentration of molecules. The measured relaxation rates may then be written as,... 

A useful approach to searching for possible binding sites is to look at sequence profile information from MSAs and to map this information onto 3D structures.The... 

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