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Positron emission tomography development

One of the great challenges facing medical science is how to diagnose and treat afflictions of the brain such as Alzheimer s disease, hi part this is because we cannot see directly inside an active human brain. Recently, however, medical researchers have developed a powerful diagnostic tool called positron emission tomography (PET). [Pg.61]

Chugani, H. T., Phelps, M. E. Mazziotta, J. C. (1987). Positron emission tomography study of human brain functional development. Ann. Neurol 22, 487-97. [Pg.240]

Stocklin G, Pike VW (eds) (1993) Radiopharmaceuticals for positron emission tomography. Cox PH (series ed) Development in nuclear medicine, vol 24, Klimder Academic Publishers, Dordrecht... [Pg.251]

Aboagye EO, Price PM, Jones T. In vivo pharmacokinetics and pharmacodynamics in drug development using positron-emission tomography. Drug Discov Today 2001 6 293 02. [Pg.78]

M. Bergstrom, A. Grahnen, B. Langstrom, Positron emission tomography microdosing A new concept with application in tracer and early clinical drug development, Eur. J. Clin. Pharmacol. 59 (2003) 357-366. [Pg.79]

A recent development in nuclear medicine that illustrates how advances in basic research are transformed into practical applications is positron emission tomography or PET. PET creates a three-dimensional image of a body part using positron emitting isotopes. Positrons, positively charged electrons, are a form of antimatter. Antimatter consists of particles that have the same mass as ordinary matter, but differ in charge or some other property. For example, antipro-... [Pg.254]

Automated radionuclide generators capable of providing precise dose delivery of multi-millicurie amounts of short-lived positron emitters on demand from a safe and easily operated system are an attractive alternative to on-site cyclotrons for positron emission tomography. The availability of curie quantities of parent radionuclides from national laboratories and the development of microprocessor automation makes it feasible to utilize these generators in the clinical setting. [Pg.118]

Renewed interest in the fluorination of quaternary ammonium salts is prompted by the need for rapid fluorination techniques to incorporate 18F (t /f 110 mm) in positron emission tomography (PET) studies One promising approach is displacement of trimethylammomum ion, bound directly to an aromatic ring, by fluoride ion This technique was initially developed with substituted phenyltnmeth-ylammomum perchlorates and unlabeled cesium fluoride in dimethyl sulfoxide or acetonitrile [73] (equation 14)... [Pg.279]

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See also in sourсe #XX -- [ Pg.217 ]



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