Portfolio , identification

Answers to the first question can be illustrated by giving some examples (see Table 1). Eastman Chemical reengineered its innovation process and doubled the value of its R D portfolio (71—74). A team at Eastman was asked to provide (/) an assessment of the then-current innovation process, (2) a vision of the ideal process, (3) a flow chart of the modified process, (4) measures of the process, and (5) key roles and responsibilities. The team identified four main subprocesses needs identification, concept development, implementation, and market development. 

Diverse and focused approaches are likely to continue to provide complementary benefits. The portfolio of techniques will provide a more effective and comprehensive approach to the identification of an NCE for the number of drug targets being revealed through the Human Genome Mapping Project. 

Materials (ASTM).94 In addition, the National Renewable Energy Laboratory95 (NREL) has developed and validated a collection of standard laboratory analytical procedures specifically for the compositional analysis of biomass including, but going beyond those of the ASTM. These wet chemical methods of analysis are based on the fractionation of the biomass sample and the isolation of purified fractions that can be quantified using conventional analytical instruments.96 These methods are primarily used in feedstock-specific portfolios containing analysis methods for each of the relevant constituents. In most cases, these portfolios enable the identification and quantification of greater than 95 percent of the dry mass of biomass feedstock and biomass-derived materials. 

By the end of 2002, the Aventis project portfolio was transformed. Of the 139 projects in the LI phase, the kinase and GPCR target families each contributed 19%, the protease and ion channels/transporters about 8% each. For projects in the candidate identification phase, GPCR, kinase, and protease target families each contributed about 20% of the compounds and ion channels/transporters about 12% of the compounds in the portfolio. 

While MV analysis stiU represents the current paradigm, other approaches to portfolio optimization exist and may eventually displace it. Value-at-risk simulation methodologies may ultimately prove more than tangential. Even so, for many practitioners there is stiU a long way to go before forecasting techniques, asset identification, md time horizon considerations are satisfactorily inte-... 

There is no formal portfolio optimization process in place. Emphasis is only on new product introduction without formal review and identification of products to be retired. (Discontinued from the product portfolio). 

Identification of a set of common core hazards. To ensure a common approach to hazard identification and analysis, it is essential that the same set of core hazards is used as a template stracture for hazard log groupings across the progranmie and at system hazard log level across to the project portfolio-project level. 

Brian Flannery Just a very quick couple of things to add. I think it s easy to try to make a list of things that might be useful, but I think more to the point is that you would probably have to be thinking in terms of creating a process with some scenarios or portfolios, some identification of issues, and their link. If you make progress in one area, if you overcome a barrier, it can suddenly open up a whole new chain of thought. 

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