GPCRs targeting

Bioprint Cerep [http //www.cerep.fr/] Contains extensive data on G-protein-coupled receptors (GPCRs), targeted toward drug discovery... 

S. A., Okun, L, Ivashchenko, A.A., and Savchuk, N.P. Property-based design of GPCR-targeted library./. Chem. Inf. Comput. Sci. 2002, 42, 1332-1342. 

In Chapter 5, Prof Didier Rognan from the University Louis Pasteur of Strasbourg elaborates on the basis of the GPCR target family, a concept for the in silico screening of the protein structure repertoire and of protein families in general. 

Mason and coworkers reported one of the first examples of a target class library design utilizing 3D pharmacophore descriptors (20). In this example, the authors designed a set of GPCR-targeted libraries based on Ugi chemistry... 

In the published example, 502 compounds from the MDL Drug Data Report (MDDR) (26) that were active against a GPCR target and also contained a biphenyl tetrazole moiety were used to generated a privileged four-point 3D... 

For example, one might design a GPCR target class library in which the coverage of GPCR-relevant 3D pharmacophores is maximized, while the coverage of PGP substrate pharmacophores is minimized in the selected products. 

Recent studies have explored several GPCR targets with respect to ligand-receptor binding interactions using site-directed mutagenesis to explore agonist... 

Thomsen, W., J. Frazer, and D. Unett. 2005. Functional assays for screening GPCR targets. Curr. Opin. Biotechnol. 16, 655-665. 

Ligand-based Template Design for GPCR-targeted Libraries I 315... 

Figure 9 Two examples of GPCR target class libraries prepared by solid-phase synthesis reported by industrial groups. In both cases, an example of a neurokinin I receptor ligand discovered is shown...

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