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Porosity spray dried particles

Microcrystalline cellulose is one of the most commonly used filler-binders in direct compression formulations because it provides good binding properties as a dry binder, excellent compactibility, and a high dilution potential. It also contributes good disintegration and lubrication characteristics to direct compression formulas. When compressed, microcrystalline cellulose undergoes plastic deformation. The acid hydrolysis portion of the production process introduces slip planes and dislocations into the material. Slip planes, dislocations, and the small size of the individual crystals aid in the plastic flow that takes place. The spray-dried particle itself, which has a higher porosity compared with the absolute porosity of cellulose, also deforms... [Pg.175]

The spray-dried powders have a small particle size (10-100 pm) with poor handling properties. Very often in the food industry, at the outlet of the spray-drying chamber, the spray-dried particles are modified by additional treatment such as agglomeration, allowing the modification/increase of powder size/porosity and improvement of solubility/dispersibility properties (i.e., instant powder, decrease of fine particles proportion) (Buffo et al., 2002). [Pg.845]

Porosity of Spray-Dried Particles and Species Distribution... [Pg.280]

Probably the major determinant of shelf-life of spray dried flavorings is the porosity of the dried particle to oxygen. [Pg.63]

Two main characteristics of spray drying are the short drying time and the porosity and small, rounded particles of product. Short... [Pg.269]

The physical characteristics of final dosage forms such as texture (porosity and surface area) and particle size distribution can affect the dissolution rate, and therefore the bioavailability of the product. It is common to see an increase in particle size when scaling up, therefore to anticipate the in vitro release profiles for a Spray Dried Drug Product (SDDP) manufactured at a larger scale, we have evaluated the influence of particle size and texture on dissolution in the case of a laboratory scale SDDP. [Pg.533]

These processes complement spray drying, especially when larger particles are needed. Compaction results in a compressed product with low porosity, i.e. more strength. Agglomeration, in contrast, produces a fluffy powder with high porosity, ideally suited for applications that which call for instant dissolving. [Pg.104]

In summary of foam-spray drying, all available literature results confirm a strong effect of feed foaming on final product properties of porous and skin-forming materials, for example, an increase of Sauter mean diameter and porosity of the products decrease of bulk, tap density, and apparent density and effect on particle morphology. Foam-spray drying enhances retention of highly volatile substances and... [Pg.485]


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See also in sourсe #XX -- [ Pg.280 ]




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Dry-spraying

Particle drying

Porosity particle

Spray dried

Spray drying

Spray porosity

Spray-dried particle

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