Death, premature

Reproductive toxicity Male or female reproductive system Decreased libido and impotence Infertility Interrupted pregnancy (abortion, fetal death, premature delivery) Infant death or childhood morbidity Altered sex ratio and multiple births Chromosome abnormalities and birth defects Childhood cancer... 

Premature death of ill and elderly. Healthy people will experience adverse symptoms that affect their normal activity. 

This new standmd, as revised from USEPA s original proposal, will provide new protections to nearly 70 million Americans, and will prevent appro.ximately 15,000 premature deaths each year... 

Burning fossil fuels can release air pollutants such as carbon dioxide, sulfur oxides, nitrogen oxides, ozone, and particulate matter. Sulfur and nitrogen oxides contribute to acid rain ozone is a component of urban smog, and particulate matter affects respiratory health. In fact, several studies have documented a disturbing correlation between suspended particulate levels and human mortality. It is estimated that air pollution may help cause 500,000 premature deaths and millions of new respiratory illnesses each year. 

Hanvelt et al. (1994) estimated the nationwide indirect costs of mortality due to HIV/AIDS in Canada. A descriptive, population-based economic evaluation study was conducted. Data from Statistics Canada were used, which contained information about aU men aged 25-64 years for whom HIV/AIDS or another selected disease was listed as the underlying cause of death from 1987 to 1991. Based on the human capital approach, the present value of future earnings lost for men was calculated. The estimated total loss from 1987 to 1991 was US 2.11 billion, with an average cost of US 558,000 per death associated with HIV/AIDS. Future production loss due to HIV/AIDS was more than double during the period 1987 to 1991, from US 0.27 to US 0.60 billion. A more comprehensive update of this smdy was presented by Hanvelt et al. (1996). The same database and the same data section but for the calendar years 1987-1993 was used. The indirect cost of future production due to HIV/AIDS in Canada based on the human capital approach for that period was estimated to be US 3.28 billion. The authors also calculated the willingness-to-pay to prevent premature death due to HIV/AIDS, which was estimated based on... 

Even a moderate quantity of salt reaching the leaves has a drastic effect on photosynthesis and leaf ultrastructure, much more than could be accounted for by the average tissue concentration (Flowers etal., 1985). Salt may accumulate in the apoplast (because it is not taken up fast enough by the cells of the leaf), and this would result in severe localised water deficit (Oertli, 1968). Differences in apoplast/protoplast balance are thought to be responsible for varietal differences in tissue salt load which can be accommodated (tissue tolerance Yeo Flowers, 1986). The xylem concentration of Na" is very much lower to young leaves than to older leaves (Yeo et al., 1985). This is advantageous in salt resistance because it means that at least some leaves are protected from salt, which otherwise causes premature leaf death (Yeo Flowers, 1984 Fig. 2). 

Cancer is a major cause of premature death in modern society. In vitro and animal research indicates that tea, mainly green tea, may be effective against a wide variety of cancers. Activity has been observed in vitro at all three levels of cancer progression, namely initiation, promotion and transformation (Mitscher et al, 1997). 

Diabetes continues to be a major cause of excessive morbidity, severe disability and premature death in Western populations. In developed countries, the cost of diabetes to society may be estimated to be as high as 5% of the total health costs, much of which relates to the chronic vascular complications of this disorder (Williams, 1991). The vascular lesion in diabetes consists of (1) microangiopathy, distinguished by thickening of capillary basement membranes resulting in increased vascular permeability, which is clinically manifested as diabetic retinopathy (Fig. 12.1a) and/or nephropathy (Fig. 12.1b), and (2) macroangiopathy (Fig. 12.2),... 

Rheumatoid arthritis (RA) is a complex systemic inflammatory condition manifesting initially as symmetric swollen and tender joints of the hands and/or feet. Some patients may experience mild articular disease, whereas others may present with aggressive disease and/or extraarticular manifestations. The systemic inflammation of RA leads to joint destruction, disability, and premature death. 

RA reduces a patient s average life expectancy by 3 to 10 years, but RA alone rarely causes death.11,12 Instead, specific comorbidities contribute to premature death independent of safety issues surrounding the use of immunomodula-ting medications. O The comorbidities with the greatest impact on morbidity and mortality associated with RA are (1) cardiovascular disease, (2) infections, (3) malignancy, and (4) osteoporosis.11,12... 

Many of these reactions are related to the quantity of excipient found in a dosage form. Benzyl alcohol benzalkonium chloride, propylene glycol, lactose, and polysorbates are all associated with dose-related toxic reactions [52-54], Large-volume parenterals containing 1.5% benzyl alcohol as a preservative have caused metabolic acidosis, cardiovascular collapse, and death in low birth weight premature neonates and infants. The cumulative dose of benzyl alcohol ranged from 99 to 234 mg/kg per day in these patients [55,56], Dose-related adverse effects to excipients are of particular concern in the preterm, low birth weight infant because... 

Certain areas are unusually susceptible to air pollution disasters. One during 1930, in the Meuse Valley of Belgium, caused the premature death of over 60 people. Another in 1948 at Donora, Pa., caused 20 deaths. A third resulted in the deaths of 22 people at Poza Rica, Mexico. The greatest occurred Dec. 5-9, 1952, in London, England. Over 4,000 people are estimated to have died from respiratory ailments as a result of the smog. Each of these occurred in an industrial valley at the time of a temperature inversion.16... 

How many years of life that is lost due to premature death and morbidity. Normally DALY = YOLL + YLD Years that would be saved following an intervention A generic term that includes the two most popular measures, the QALY and the DALY [46]... 

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