Polypropylenimine dendrimes

Schatzlein AG, Zinselmeyer BH, Elouzi A et al (2005) Preferential liver gene expression with polypropylenimine dendrimers. J Control Release 101 247-258... 

Kim TI, Baek JU, Zhe BC et al (2007) Arginine-conjugated polypropylenimine dendrimer as a non-toxic and efficient gene delivery carrier. Biomaterials 28 2061-2067... 

Schatzlein, A.G., Zinselmeyer, B.H., Elouzi, A., Dufes, C., Chim, Y.T., Roberts, C.J., Davies, M.C., Munro, A. et al. (2005) Preferential liver gene expression with polypropylenimine dendrimers. Journal of Controlled Release 101 247-258. 

Zinselmeyer B H, et al. (2002). The lower-generation polypropylenimine dendrimers are effective gene-transfer agents. Pharm. Res. 19 960-967. 

Data for amine terminated polypropylenimine dendrimer DAB-deudri-(NH2)i... 

Data for nitrile terminated polypropylenimine dendrimer DAB-dcndn-(CN)x... 

Newkome, G.R. and C.D. Shreiner, Poty(amidoamine), polypropylenimine, and related dendrimers and dendrons possessing different 1 —> 2 branching motifs An overview of the divergent procedures. Polymer, 2008. 49(1) p. 1-173. 

Dendrimers used for DNA delivery most commonly have positive net surface charges. The most well studied molecules for gene delivery are those based on an ethylene diamine or ammonia core with polyamidoamine (PAMAM) dendrites or those based on bufylenediamine cores and polypropylenimine (PPI) dendrites. Solubility of PAMAM dendrimers can be enhanced by partial acetylation of the reactive amino groups and they can be conjugated with various targeting entities such as folic acid to target receptors on specific cancer cells (42). 

Reetz et al.59 have introduced polypropylenimine (PPI) dendrimers as the core for building phosphine-coated constructs that can complex with Rh(COD) BF4, where COD = 1,5-cyclooctadiene, to instill the desired catalytic character. Hydroformylation of 1-octene with these metallodendrimers was shown to have turnover numbers that were comparable to those of monomeric analogs. It was pointed out that these catalysts could be easily recovered by means of membrane separation technology.60 Gong et al. have used water-soluble, phosphonated dendritic... 

ALTERNATIVE NAME, ACRONYM, TRADE NAME Polypropylenimine (POPAM) dendrimers, Astramol dendrimers... 

Alternatives to triazines exist. These include dendrimers derived from PAMAM, polypropylenimine (PPI), lysine, and phosphorus-containing dendrimers, as shown in Figure 10.2. ... 

Co(III) and NaBH4. Iterative repetition of these two steps allows one to obtain cascade polymers , as Vogtle initially described them, but in poor yields. Optimization of Vdgtle s original inefficient synthesis by Meijer and Mulhaupt in 1993 resulted in the preparation of poly(propylenimine) dendrimers (Scheme 13.9). The high yield and degree of purity obtained in this synthesis has made these dendrimers one of the most popular architectures in dendrimer chemistry. They have also been produced on an industrial scale and can be found under different names, in particular PPI (for polypropylenimine), DAB (for diaminobutane) and POPAM (for polypropylene amine), depending on the nature of the core. 

DAB-AM-4 G1), polypropylenimine octaamine (DAB-AM-8 G2), propylenimine octaamine (DAB-AM-16 G3) dendrimers Glutar aldehyde Ethylenedi amine Para-phenylenediamine... 

The versatile chemistry of the ferrocenyl moiety has also allowed for the preparation of a large number of dendrimeric structures with this group at the periphery (116-118). A series of dendrimers based upon polypropylenimine cores have been reported (119,120) and star-shaped macromolecules with ferrocene units at the periphery have been produced (121), as well as amido-ferrocene dendrimers (eg, 38) (122). A convergent approach has allowed for the synthesis of dendrimers (39) for which the ferrocene units at the periphery display electronic interaction (123). 

We have previously reported that starburst polyamidoamine (PAMAM) dendrimers i.e. PolyFect and SupeFect ) as well as polypropylenimine... 

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