Cascade polymer

Newkome GR, Moorefield CN (1996) Design, syntheses, and supramolecular chemistry of smart cascade polymers. In Muller A, Dress A, Vogtle F (eds) From simplicity to complexity in chemistry and beyond, pt 1. Vieweg Sohn, Braunschweig/Wiesbaden, p 127... 

The reaction of tertiary nitro compounds with the sodium salt of nitromethane followed by the Nef reaction provides a good method forthe preparation of quaternary aldehydes (Eq. 7.10).8 Because the nitromethyl group can be transformed into other groups such as CN, C02H, or CH2NH2, the SRN I reaction of tertiary nitro compounds with the anion of nitromethane is a synthetically useful method (Kornblum reaction).10 For example, the nitromethylation of tertiary nitro compounds has been applied for preparing starting materials for cascade polymers (Eq. 7.11).9... 

Haensler, J., and Szoka Jr., F.C., Polyamidoamine cascade polymers mediate efficient transfection of cells in culture, Bioconjugate Chemistry, 1993, 4, 372-379. 

Newkome GR, Lin X, Yaxiong C, Escamilla GH. Cascade polymer series. 27. Two-directional cascade polymer synthesis effects of core variation. J Org Chem 1993 58 3123-3129. 

Newkome GR, Moorefield CN, Baker GR, Johnson AL, Behera RK. Chemistry of micelles. 11. Alkane cascade polymers with a micellar topology micelle acid derivatives. Angew Chem 1991 103 1205-1207. 

Newkome GR, Young JK, Baker GR, Potter RL, Audoly L, Cooper D, Weis CD, Morris K, Johnson CS Jr. Cascade polymers. 35. pH dependence of hydrodynamic radii of acid-terminated dendrimers. Macromolecules 1993 26 2394-2396. 

Young JK, Baker GR, Newkome GR, Morris KF, Johnson CS Jr. Smart cascade polymers. Modular syntheses of four-directional dendritic macromolecules with acidic, neutral, or basic terminal groups and the effect of pH changes on their hydrodynamic radii. Macromolecules 1994 27 3464 -3471. 

Zhang H, Dubin PL, Kaplan J, Moorefield CN, Newkome GR. Dissociation of carboxyl-terminated cascade polymers comparison with theory. J Phys Chem B 1997 101 3494-3497. 

Polyamidoamine (PAMAM) dendrimers are non-linear polycationic cascade polymers that can bind plasmid DNA [43]. The interaction of activated PAMAM-dendrimers and plasmid DNA induces condensation of the nucleic acid. The compact transfection complexes can subsequently adhere to the cell surface and be taken up by endocytosis. 

If the branching multiplicity remains constant throughout the macromolecule, i.e. Nbl = Nh2 = = then the relationship simplifies to give Z = NcN(j. For cascade polymers possessing the same branch unit throughout the structure, the line formula may be more simply represented by ... 

Smart Cascade Polymers. Modular Syntheses of Four-directional Dendritic Macro-moleculers with Acidic, Neutral, or Basic Terminal Groups and the Effect of pH Changes on their Hydrodynamic Radii. [J. K. Young, G. R. Baker, G. R. Newkome, K. F. Morris, C. S. Johnson, Jr., Macromolecules 1994, 27, 3464-3471] [ 233],... 

Complexes of complexing agents bonded to cascade polymers for use in pharmaceuticals. [J. Platzek, H. Schmitt-Willich, H. Gries, G. Schuhmann-Giampieri, H. Vogler, H. J. Weinmann, H. Bauer, Ger. Pat. Offen. 3,938,992 1991 Chem. Abstr. 115 280870] [ 495]. 

Cascade polymers as drug carriers [K. Akiyoshi, Kagaku (Kyoto) 1994, 49(6), 422]. 

Cascade Polymers. Soft soap [Anonymous, The Economist 1991, 321, 93]. 

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