Polyphenols biological activities

Zhu, M. et al.. Plant polyphenols biologically active compounds or non-selective binders to proteins Phytochemistry, 44, 441, 1997. 

Zhu, M., Phillipson, D., Greengrass, P.M., Bowery, N.E. Cai, Y. (1997). Plant polyphenols biologically active compounds or non-selective binders to protein Phytochemistry, 44, 441-447 (and references cited therein). 

Biological activity (BA) was chosen as such parameter. The BA determined using a system and a technique for a class of natural polyphenolic bonds nicotinamide adenine dinucleotide restored (NAD H ) - ferricyanide (KjFe(CN)g) in a phosphates buffer solution. 

There is also another group of polyphenolic compounds, thus far only known through their biological activity as thrombogenic haptens.69... 

Polyphenols are endowed with different biological activities, including ... 

Anderson RA, Broadhurst CL, Polansky MM, Schmidt WF, Khan A, Flanagan VP, Schoene NW, Graves DJ. 2004. Isolation and characterization of polyphenol type-A polymers from cinnamon with insulin-like biological activity. J Agric Food Chem 52 65-70. 

Phosphate is another anion which is of biological significance as well as being biologically active. Numerous phosphate biosensors have been developed, with one based on a multi-enzyme system immobilised on a cellulose membrane on a Pt electrode being able to detect levels down to 10 8 M [104]. Simpler methods, however, use enzymes such as polyphenol oxidase combined with alkaline phosphatase bound within an electropolymerised layer based on a substituted pyrrole [ 105]. This was reported to give a sensor with a detection... 

For the production of many recombinant proteins, cellular insolubility is a major problem because it is often difficult to achieve biological activity starting with such products (57). However, because the polyphenolic protein produced in vivo is a preadhesive, in vitro activation to the adhesive form is required. Therefore, in vivo insolubility may actually be desirable in the case of the polyphenolic protein because this could result in increased resistance to yeast proteases and better product uniformity and quantity. 

It is widely accepted that polyphenols in wine are responsible for beneficial health effects (Sun et al. 2006). Particularly fran.y-resveratrol has been intensively studied and marked biological activities with regard to the prevention of cardiovascular disease and cancer have been reported (Ito et al. 2003). Other stilbenes also have properties similar to those of fran.y-resveratrol. Therefore, monitoring new stilbene derivatives in wine is of particular relevance (Guebailia et al. 2006). 

The inhibitory effects of tea against carcinogenesis have been attributed to the biologic activities of the polyphenolic fractions in tea. However, the molecular... 

Flavonoids are natural polyphenolic substances widely distributed in the different parts of plants such as fruits, bark, stems, roots, leaves and flowers. Structurally they are characterized by a pyran ring or a similar structure of three carbons. These polyphenolic compounds are well known for displaying a remarkable spectrum of biological activities, including antibacterial and antifungal properties. In the Anthemideae tribe, some of these compounds were isolated by bioassay-guided fractionation, after previously detecting antimicrobial activity on the part of the plant. 

Gossypol is a polyphenolic aldehydic compound, and it has been studied for its versatile biological activities. Gossypol s biological activities are based on direct chemical reactions, the inhibition of enzymes, and the regulation of signal transduction pathways. However, due to its toxicity, the application of gossypol is sometimes limited. 

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