Polymorphonuclear leukocytes, activation, role

Moreover,bioactive lipids maybe considered dual messengers they modulate cell functions as messengers and they become part of the response of the nervous tissue to injury, broadly referred to as the inflammatory response. This response occurs in ischemia-reperfusion damage associated with stroke, various forms of neurotrauma, infectious diseases and neurodegenerative diseases such as Alzheimer s disease. Inflammation in the nervous system differs from that in other tissues. If the blood-brain barrier is broken, blood-borne inflammatory cells (e.g. polymorphonuclear leukocytes, monocytes, macrophages) invade the intercellular space and glial cells are activated, particularly microglia, which play a prominent role in the inflammatory response. These responses may... 

Takahashi, S., Yoshikawa, T., Naito, Y., Tanigawa, T., Yoshida, N., Kondo, M. (1991). Role of platelet-activating factor (PAF) in superoxide production by human polymorphonuclear leukocytes. Lipids 26,1227-30. 

Superoxide is a product of activated polymorphonuclear leukocytes, such as the neutrophils, and has been proposed to be a mediator of inflammation. - We have evaluated the role of superoxide in acetic acid-induced, neutrophil-depend-... 

Shandelya, S. M., P. Kuppusamy, M. L. Weisfeldt, and J. L. Zweier. 1993. Evaluation of the role of polymorphonuclear leukocytes on contractile function in myocardial reperfusion injury. Evidence for plasma-mediated leukocyte activation. 87(2) 536 6. 

A further patient has been reported with quinidine-induced liver damage the causal role of the drug was confirmed by rechallenge. Liver biopsy showed an active hepatitis with focal areas of hepatocellular necrosis around which were scattered lymphocytes, plasma cells and polymorphonuclear leukocytes (33 ). 

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