Ischemia-reperfusion damage

Ischemia-reperfusion damage Stroke (A,l), cardiac failure (A), transplantation (A)... 

Moreover,bioactive lipids maybe considered dual messengers they modulate cell functions as messengers and they become part of the response of the nervous tissue to injury, broadly referred to as the inflammatory response. This response occurs in ischemia-reperfusion damage associated with stroke, various forms of neurotrauma, infectious diseases and neurodegenerative diseases such as Alzheimer s disease. Inflammation in the nervous system differs from that in other tissues. If the blood-brain barrier is broken, blood-borne inflammatory cells (e.g. polymorphonuclear leukocytes, monocytes, macrophages) invade the intercellular space and glial cells are activated, particularly microglia, which play a prominent role in the inflammatory response. These responses may... 

XOR is a cytoplasmic enzyme and a ready source of electrons for transfer to molecular oxygen to form reactive oxygen species such as superoxide and peroxide. It is therefore thought to be involved in free radical-generated tissue injury and has been implicated in the pathogenesis of ischemia-reperfusion damage. Moreover, it has recently been implicated in the production of peroxynitrite (89), and carbonate radical anion (92), both potent biological oxidants. Its exact role in lipid peroxidation, inflammation, and infection needs... 

Standardized P. ginseng extract G115 after oral administration protects rat heart from ischemia-reperfusion damage induced by hyperbaric oxygen. 

R. Maffei-Facino et al., Panax ginseng protects rat heart from ischemia-reperfusion damage induced by hyperbaric oxygen, Paper presented at 2nd Int. Congress on Phytomedicine, Sept. 11-14, Munich, Germany, 1996. 

Weisbrot-Lefkowitz, M., Reuhl, K., Perry, B., Chan, P. H., Inouye, M., and Mirochnitchenko, O. (1998). Overexpression of human glutathione peroxidase protects transgenic mice against focal cerebral ischemia/reperfusion damage. Brain Res. Mol. Brain Res. 53, 333—338. 

Maffei, F.R. Carini, M. Aldini, G. Berti, F. Rossoni, G. Panax ginseng administration in the rat prevents myocardial ischemia-reperfusion damage induct by hyperbaric oxygen evidence for an antioxidant intervention. Planta Med. 1999, 65, 614-619. 

Oxidation of cellular components by reactive oxygen species (ROS) and free radicals is involved in a variety of serious acute and chronic diseases inflammation [56], ischemia-reperfusion damage [57,58], limg disease [59], kidney damage [60], atherosclerosis, diabetes, allergies, cancer and aging [61]. 

Toriu N, Akaike A, Yasuyoshi H, Zhang S, Kashii S, et al. 2000. Lomerizine, a Ca channel blocker, reduces glutamate-induced neurotoxicity and ischemia/reperfusion damage in rat retina. Exp Eye Res 70 475-484. 

Chiang SK, Lam TT. Post-treatment at 12 or 18 hours with 3-aminobenxamide ameliorates retinal ischemia-reperfusion damage. Invest Ophthalmol Vis Sci 2000 41(10) 3210-4. 

Tanaka, H. Matsui, S. Kawanishi, T. Shigenobu, K. Use of chloride blockers a novel approach for cardioprotection against ischemia-reperfusion damage. J. Pharmacol. Exp. Ther. 1996, 278, 854-861. 

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