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Biodegradable polymeric implants

As for non-degradable polymeric implants, biodegradable polymeric implants are divided into two main... [Pg.89]

Such limitations prompted scientists to develop biodegradable polymeric implants. Degradation can take place via ... [Pg.88]

The drag release for biodegradable polymeric implants is governed not by diffusion through a membrane, but by degradation of the polymer membrane or matrix. [Pg.89]

Kimura H.-O.Y., Hashizoe, M., Nishiwaki, H., Honda, Y. and Ikada, Y. (1994) A new vitreal drug delivery system using an implantable biodegradable polymeric device. Investigative Ophthalmology and Visual Science, 35 2815-2819. [Pg.318]

Zoladex (gosorelin acetate implant) biodegradable polymeric particles capable of continuously delivering gosorelin for 3 months as a palliative treatment for advanced prostate cancer. [Pg.368]

The Norplant device has been somewhat controversial, however, due to difficulties associated with its removal. A second example of an implantable drug delivery system is Zoladex, which is an implantable biodegradable lactide/glycolide polymeric delivery system for the administration of goserelin acetate. It is available in one-month and three-month presentations and can be injected through a wide-bore needle. [Pg.346]

Hashizoe M, Ogura Y, Takanashi T, Kunou N, Honda Y, Ikada Y. Implantable biodegradable polymeric device in the treatment of experimental proliferative vitreoretinopathy. Curr Eye Res 1995 14 473-477. [Pg.190]

Sanders, L., et al., Prolonged controlled release of Naferlin, a luteinizing hormonereleasing hormone analogue, from biodegradable polymeric implants. Journal of Pharmaceutical Science, 1986, 75, 356-360. [Pg.279]

Figure 3 lists the relative water sorption of a variety of polymeric blomaterlals. Figure 4 Indicates the most commonly encountered biodegradable repeating bond units In polymer backbones. Such polymers generally degrade via hydrolysis reactions. Blodegradablllty may or may not be desired In a polymeric Implant. Figure 3 lists the relative water sorption of a variety of polymeric blomaterlals. Figure 4 Indicates the most commonly encountered biodegradable repeating bond units In polymer backbones. Such polymers generally degrade via hydrolysis reactions. Blodegradablllty may or may not be desired In a polymeric Implant.
Domb AJ, Rock M, Perkin C, Yipchuck G, Broxup B, Villemure JG. Excretion of a radiolabelled anticancer biodegradable polymeric implant from the rabbit brain. Biomaterials 1995 16 1069-1072. [Pg.510]

This degradation process can also release biomaterial-associated components such as chemical initiators, inhibitors, residual monomers, antioxidants, or plasticizers, which can invoke adverse response from the host immune system [47], Though the in vivo biodegradation mechanism of polymeric implants is not firmly understood, hydrolysis and oxidation are two chemical pathways often implicated in this process [45],... [Pg.312]

Domb, A.J., Rock, M., Schwartz, J., Perkin, C., Yipchuk, G., Broxup, B., Villemure, J., 1994. Metabolic disposition and ehmination studies of a radiolabeUed biodegradable polymeric implant in the rat brain. Biomaterials 15, 681—688. [Pg.183]

Sanders, L. M., Kell, B. A McRae, G. I., and Whitehead, G. W., 1986, Prolonged control-led-release of Nafarelin, a luteinizing hormone-releasing hormone analogue, from biodegradable polymeric implants Influence of composition and molecular weight of polymer,... [Pg.90]

Dunn, R.L., Yewey, G.L., Duysen, E.G., Poison, A.M., Southard, G.L. (1994) In-situ forming biodegradable polymeric implants for tissue regeneration. Polymer Reprints, 35, 437. [Pg.35]

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See also in sourсe #XX -- [ Pg.99 , Pg.100 , Pg.101 , Pg.102 , Pg.103 , Pg.104 , Pg.105 , Pg.106 ]



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