Polymer degradation protein

O Hagan DT, Jeffery H, Davis SS (1994) The preparation and characterization ofpoly (lactide-co-glycolide) microparticles III. Microparticle/polymer degradation rates and the in vitro release of a model protein. Int J Pharm 103 37-45... 

Panyam J, Dali MM, Sahoo SK et al (2003) Polymer degradation and in vitro release of a model protein from poly(D, L-lactide-co-glycolide) nano- and microparticles. J Control Release 92 173-187... 

Kaplan, D. L. (1998). Fibrous proteins-silk as a model system. Polym. Degrad. Stab. 59, 25-32. 

Julinova M, Kupec J et al (2010) Lignin and starch as potential inductors for biodegradation of films based on poly(vinyl alcohol) and protein hydrolysate. Polym Degrad Stab 95 225-233... 

Sua J-E, Yuanb XY et al (2010) Properties stability and biodegradation behaviors of soy protein isolate/poly(vinyl alcohol) blend films. Polym Degrad Stab 95 1226-1237... 

The degradation rate can be controlled using acidic and basic excipients acidic excipients increase the degradation rates and facilitate a zero-order release rate over a 2-week period (Sparer et al. 1984). Basic additives increase the degradation time of the polymers and create a polymer that degrades specifically at the surface (Heller 1985). By careful choice of the excipient added, the degradation rate can be closely controlled. No experiments have shown the use of these polymers with proteins or peptides. This is not, however, indicative of the fact that these polymers are not compatible with proteins or peptides, but they are probably not the most appropriate polymeric carrier for oral delivery of biomacromolecules. 

Degradation can take place by one or both mechanisms. For example, natural polymers such as albumin may be used such proteins are not only water-soluble, but are readily degraded by specific enzymes. The terms degradation, dissolution and erosion are used interchangeably in this chapter, and the general process is referred to as polymer degradation. 

The study by Determan et al. [224] focuses on the effects of polymer degradation products on the primary, secondary, and tertiary structure of TT, OVA, and lysozyme after incubation for 0 or 20 days in the presence of ester (lactic acid and glycolic acid) and anhydride [sebacic acid and l,6-bis(p-carboxyphenoxy)hexane] monomers. The structure and antigenicity or enzymatic activity of each protein in the presence of each monomer was quantified. SDS-PAGE, circular dichroism, and fluorescence spectroscopy were used to assess/evaluate the primary, secondary, and tertiary structures of the proteins, respectively. ELISA was used to measure changes in the antigenicity of TT and OVA and a fluorescence-based assay was used to determine the enzymatic activity of lysozyme. TT toxoid was found to be the most stable in the presence of anhydride monomers, while OVA was most stable in the... 

Park,T. G., Lu, W., and Crotts, G. (1995), Importance of in vitro experimental conditions on protein release kinetics, stability and polymer degradation in protein encapsulated poly(D,L-lactic acid-co-glycolic acid) microspheres,/. Controlled Release, 33,211-222. 

Determan, A. S., Wilson, J. H., Kipper, M. J., Wannemuehler, M. J., and Narasimhan, B. (2006), Protein stability in the presence of polymer degradation products Consequences for controlled release formulations, Biomaterials, 27, 3312-3320. 

Luminescence properties of and phenomena in polymer systems continues to be widely researched in connection with mechanisms of polymer degradation and stabilization, molecular dynamics, solubility, blend miscibility, and solar energy harnessing. A number of interesting reviews have appeared. Molecular dynamics of polymers in solution and in the solid state have been covered, as has excimer formation,photoresponsive polymers,behaviour of polymer gels, and photochromic phenomena. Photoisomerization of enzymes and model compounds has also been discussed in depth, with particular emphasis on proteins and synthetic polymers containing azo-compounds or spirobenzopyrans. ... 

The release of a number of drugs from polyanhydride matrices has been studied including ciprofloxacin, p-nitroaniline, cortisone acetate, insulin, and a variety of proteins. ° In many instances, drug release was reported to coincide with polymer degradation. The biocompatibility of polyanhydrides has... 

Septicin antibacterial implant for the treatment of chronic bone infections have been developed [21-24]. The multidisciplinary concept of polymeric implants has expanded to include research on the chemistry and characterization of polymers, experimental and theoretical polymer degradation and drug release, toxicology and metabolism, and research in specific fields of applications such as cancer, proteins and hormones delivery, infectious diseases, and brain disorders. This chapter concentrates on the chemistry and characterization of polyanhydrides with a brief description on recent applications of polyanhydrides. 

Otaigbe, U.J. O.D. Adams. Bioabsorbable soy protein plastic composites Effect of polyphosphate fillers on water absorbtion and mechanical properties. /. Environ. Polym. Degrad. 1997b, 5, 199-208. 

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