Pharmacokinetics asparaginase

Avramis, V. and Panosyan, E. 2005. Pharmacokinetic/pharmacodynamic relationships of asparaginase formulations - the past, the present and recommendations for the future. Clinical Pharmacokinetics 44(4), 367-393. 

Some of the previously unavailable enzymes for therapeutic use include domase (Pulmozyme), imiglucerase (Cerezyme), asparaginase, tissue-type plasminogen activator (Activase), and related drugs (Retavase). Detailed information about these products and their clinical use is provided in Part II in the form of monographs. Information relevant to pharmacokinetics and molecular characteristics can be found in Appendixes I and II. 

Pharmacokinetics The elimination half-life of pegaspargase has been estimated to be 5.7 days, compared with a half-life of a few minutes up to 5 hours for L-asparaginase, and its volume of distribution has been estimated to be 2.1 liters/m. ... 

Hawkins, D. S., Park, J. R., Thomson, B. G., Felgenhauer, J. L., Holcenberg, J. S., Panosyan, E. H. and Avramis, V. I. (2004). Asparaginase pharmacokinetics after intensive polyethylene glycol-conjugated L-asparaginase therapy for children with relapsed acute lymphoblastic leukemia. Clin. Cancer Res. 10, 5335-5341. 

J. PUtter. Pharmacokinetic behaviour of 1-asparaginase in men and animals. Experimental and Clinical Effects of l-Asparaginases (E. Grundmann and H. F. Oettgen, eds.). RRCR, Springer, Heidelberg, 1970, p. 64. 

V. Wahn, U. Fabry, D. Korholz, et al. Modified pharmacokinetics of 1-asparaginase from E. coli by formation of specific antibodies to 1-asparaginase of different immunoglobulin classes in children with acute lymphocytic leukemia. Pediatr. Pharmacol 5 303 (1983). 

L-Asparaginase (Elspar) is given parenterally. Three different preparations of L-asp are used clinically. Their pharmacokinetics and immunogenicity differ significantly after intravenous administration. 

Veronese, M., Monfardini, C., Caliceti, P, Schiavon, O., Scrawen, M. D., Beer, D. (1996), Improvement of pharmacokinetic, immunological and stability properties of asparaginase by conjugation to linear and branched monomethoxy poly(ethylene glycol), J. Control Release, 40,199-209. 

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