Polychlorinated biphenyls proliferation

Levin, M.J., De Guise, S., and Ross, P.S., Association between lymphocyte proliferation and polychlorinated biphenyls in free-ranging harbor seal (Phoca vitulina) pups from British Columbia, Canada, Environ. Toxicol. Chem. 24, 1247, 2005. 

A.S. Stack, S. Altaman-Hamamdzic, P.J. Morris, S.D. London and L. London, Polychlorinated biphenyls mixtures (Arocolors) inhibit LPS-induced murine splenocyte proliferation in vitro, Toxicology, 139 (1999) 137-154. 

The use of nonneuronal cell types may provide initial information on whether a chemical may have differential effects, or display different potencies, in neuronal versus nonneuronal cells. For example, a battery of seventeen different cell types, including cell lines and primary cells (both neuronal and glial), human and rat cells, and nervous system and nonnervous system cells, was utilized to assess the toxicity of known developmental neurotoxicants, such as methyl-mercury and polychlorinated biphenyls (PCBs).24 Endpoints were cell viability and cell proliferation, and a summary of results for methylmercury and PCB-153 is shown in Table 8.5. This simple approach would flag methylmercury as a potential neurotoxicant, as toxicity was greater in neuronal cells than in other cell types. PCB-153 would also be flagged as a potential neurotoxicant, though... 

Tharappel JC, Lee EY, Robertson LW, et al. Regulation of cell proliferation, apoptosis and transcription factor activities during the promotion of liver carcinogenesis by polychlorinated biphenyls. Toxicol Appl Pharmacol 2002 179(3) 172-84. 

Schulze-Stack A, Altman-Hamamdzic S, Morris PJ, et al. 1999. Polychlorinated biphenyl mixtures (Aroclors) inhibit EPS-induced murine splenocyte proliferation in vitro. Toxicology 139 137-154. 

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