Poly-L-lactide-co-glycolide

To provide for prolonged, site-specific delivery of NGF to the tissue in a convenient manner without affecting the properties of the conduit, biodegradable polymer microspheres of poly(L-lactide)co-glycolide... 

Figure 27. Human osteoblast-like MG 63 cells in cultures on porous (A) or fibrous (B) poly(L-lactide-co-glycolide) scaffolds. A A summarizing picture of horizontal optical sections. The depth of cell ingrowth into the pores (average pore diameter of 400-600 mm) is indicated by spectral colors (blue 0-60 mm, green 80-160 mm, yellow 180-220 mm, orange 240-300 mm, red 320-400 mm, violet 420-480 mm). Day 14 after seeding, cells stained with propidium iodide. B cells grown for 4 days in static culture followed by 2 days in dynamic perfusion cell culture system. Cell membrane stained with Texas Red C2-maleimide and the nuclei counterstained with Hoechst 33342. Leica TCS SP2 confocal microscope, objective 5x (A) or lOx (B) [37].

The same annealed braids were also subjected to in vivo BSR testing. The results are shown in Figure 1 for both the poly(L-lactide) and 95/5 poly(L-lactide-co-glycolide). These data showed that during the first 4-5 months, both sutures retained... 

Table 2. In Vitro BSR (pH 7.27 buffer, 50 C) of Poly(i lactide) and 95/5 Poly(L-lactide-co-glycolide) Braids...

Two terpolymers of poly(L-lactide-co-glycolide) were prepared in this application that had enhanced fracture toughness by incorporating -y-caprolactone by ring-opening polymerization using either stannous octoate or stannous trifluoromethane sulfonate as the catalyst. The products synthesized by this method were ... 

Poly[(L-lactide-co-glycolide)-b-(glycolide-co-7-caprolactone)] was also prepared as... 

Poly(L-lactide-co-glycolide) 75 25 0 l-PLGA (75 25) Pursasorb PLG PURAC 1,4-Dioxone-2,5-dione, polymer with (3Scis)-3,6-dimethyl-l, 4-dioxane-2,5-dione [30846-39-0]... 

Ignatius, A. A., Claes, L. E. In vitro biocompatibility of bioresorbable polymers poly(l, dl-lactide) and poly(l-lactide-co-glycolide). 1996,17(8), 831-839. 

ESE Eser, H. and Tihminlioglu, F., Determination of thermodynainic and transport properties of solvents and non solvents in poly(L-lactide-co-glycolide), J. Appl. 

Tsuji, H. and Ikada, Y. (1994) Stereocomplex formation between enantiomeric poly(lactic acid)s. X. Binary blends from poly(D-lactide-co-glycolide) and poly(L-lactide-co-glycolide). Journal of Applied Polymer Science, 53, 1061-1071. 

Bini, T.B., Gao, S, Wang, S., and Ramakrishna, S. (2006) Poly(l-lactide-co-glycolide) biodegradable microfibers and electrospun nanofibers for nerve tissue engineering an in vitro study. J. Mater. Sci., 41, 6453-6459. 

Panyam J, Labhasetwar V (2003) Dynamics of endocytosis and exocytosis of poly (L-lactide-co-glycolide) nanoparticles in vascular smooth muscle cells. Pharm Res 20 212-220... 

Dong, J., Liao, L., Ma, Y., Shi, L., Wang, G.X., Fan, Z., Li, S., Lu, Z., 2014a. Enzyme-catalyzed degradation behavior of L-lactide/trimethylene carbonate/glycolide terpolymers and a composite with poly(L-lactide-co-glycolide) fibers. Polymer Degradation and Stability 103, 26-34. 

Han, Y.R., Jin, X.Y., Yang, J., Fan, Z.Y., Lu, Z.Q., Zhang, Y., Li, S.M., 2012b. Totally bioresorbable composites prepared from poly(L-lactide)-co-(trimethylene carbonate) copolymers and poly(L-lactide)-co-(glycolide) fibers as cardiovascular stent material. Polymer Engineering Science 52, 741—750. 

Kasperczyk, J. Microstructural analysis of poly[(L-lactide)-co-(glycolide)] by and C NMR spectroscopy. Polymer 1996, 37, 201-203. 

Bini T B, Gao S, Tan T C, Wang S, Lim A, Hai L B and Ramakrishna S (2004) Electrospun poly(L-lactide-co-glycolide) biodegradable polymer nanofibre tubes for peripheral nerve regeneration, Nanotechnology 15 1459-1464. 

Chanfreau S, Mena M, Porras-Domfnguez J, Ramfrez-Gilly M, Gimeno M, Roquero P, et al. Enzymatic synthesis of poly-l-lactide and poly-l-lactide-co-glycolide in an ionic liquid. Bioprocess Biosyst Eng 2010 33 629-38. 

On the other hand, as reported by Vert and coworkers, in the cases of PDLLA [96], PLLA [23, 28], poly(L-lactide-co-glycolide) (poly(L-lactic acid-co-glycolic acid) (P(LLA-co-GA))) [123], P(DLLA-co-GA) [123], PDLLA-Z -PEO [198], and PLLA-Z -PEO-Z -PLLA [205], NHD proceeds via... 

FIGURE 21.13 Mn change of amorphous PLLA having high and low molecular weights (PLLA(H) and PLLA(L), respectively), P(LLA-co-DLA) (77/23), poly(L-lactide-co-glycolide) (P(LLA-C( -GA)) (81/19), and poly(L-lactide-co-8-caprolactone) (P(LLA-co-CL)) (82/18) with respect to hydrolytic degradation in a phosphate-buffered solution [39, 40, 159]. 

During the syntheses of PLLA and poly(L-lactide-co-glycolide) (PLLGA) in the ionic liquid l-hexyl-3-methylimidazolium hexafluoro-phosphate [HMIM][PF6] mediated by Novozyme-435, the highest PLLA yield (63%) was obtained at 90 "C with a MW... 

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