Peripheral nerves, regeneration

Current polymeric entubulization repair methods for peripheral nerve regeneration use various nondegradable and biodegradable materials. The most common nondegradable material investigated has been silicone rubber. Medical grade silicone rubber, polydimethylsiloxane, maintains its shape and can be filled with neurotrophic factors or extracellular... 

Fu, S. and Gordon, T. 1997. The cellular and molecular basis of peripheral nerve regeneration. Molecular Neurobiology 14, 67-116. 

The neuregulins also act on Schwann cells to stimulate motility and migratory activity. It is postulated that this interaction provides a mechanism by which neurons can influence glial metabolism and behavior, which are important both in development and for peripheral nerve regeneration. 

Fawcett, J. W., Rosser, A. E. and Dunnett, S. B. Peripheral nerve regeneration. In Brain Damage, Brain Repair. New York Oxford University Press, 2001. 

Peripheral nerve regeneration Nerve lesion nerve development Time course Comparison suggests regeneration partially recapitulates development [29]... 

Ebadi, M. et al. (1997). Neurotrophins and their receptors in nerve injury and repair. Neurochem. Int. 30, 347-374. Fu, S. Gordon, T. (1997). The cellular and molecular basis of peripheral nerve regeneration. Mol. Neurobiol. 14, 61-116. 

Rong LL, Trojaborg W, Qu W, Rostov K, Yan SD, Gooch C, Szabolcs M, Hays AP, Schmidt AM. 2004a. Antagonism of RAGE suppresses peripheral nerve regeneration. Faseb J 18(15) 1812—1817. 

Aebischer, P., Salessiotis, A.N., and Winn, S.R. 1989. Basic fibroblast growth factor released from synthetic guidance channels facilitates peripheral nerve regeneration across long nerve gaps. J. Neurosci. Res. 23 282-289. 

Liu JJ et al (2010) Peripheral nerve regeneration using composite poly(lactic acid-caprolactone)/nerve growth factor conduits prepared by coaxial electrospinning. J Biomed Mater Res A 96(1) 13-20... 

Electrospun Fibers as Substrates for Peripheral Nerve Regeneration... 

Keywords Artificial implants Biomaterials Electrospinning Extracellular matrix Growth factors Peripheral nerve Regeneration... 

Consequently, natural peripheral nerves provide the ideal template for bio-mimetic designs of artificial nerve conduits. Ideally, such constructs would also include molecular signals that guide and support regeneration in the natural environment. Since research on molecular processes associated with peripheral nerve regeneration has accumulated an immense corpus of data over the last half century, we can only mention those pertinent signal transduction pathways that have been considered in the functionalization of nerve constructs. 

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