Poly-anhydride ester

Erdmann, L., Macedo, B., and Uhrich, K. E. Degradable poly(anhydride ester) implants Effects of localized salicylic acid release on bone. Biomaterials 21(24) 2507-2512, 2000. [Pg.300]

Poly(anhydride - ester) containing salicylic acid... [Pg.475]

Researchers at Rutgers University have developed biocompatible polymers that degrade into nonsteroidal anti-inflammatory drugs. For example, the reaction of two equivalents of benzyl salicylate and one equivalent of sebacoyl chloride forms a poly(anhydride ester) called PolyAspirin, which hydrolyzes to salicylic acid (an anti-inflammatory agent) and sebacic acid, which is excreted. This technology can perhaps be used for localized drug delivery at specific sites of injury. What is the structure of PolyAspirin ... [Pg.1175]

Erdmann, L. Uhrich, K.E. Synthesis and degradation characteristics of salicylic acid-derived poly(anhydride-esters). Biomaterials 2000, 21 (19), 1941-1946. [Pg.2255]

Schmeltzer, R. Anastasiou, T. Uhrich, K. Optimized synthesis of salicylate-based poly (anhydride-esters). Polym. Bull. 2003, 49 (6), 441 48. [Pg.2255]

Anastasiou, T. Uhrich, K. Aminosalicylate-based biodegradable polymers synthesis and in vitro characterization of poly(anhydride-esters) and poly(anhydride-amides). J. Polym. Sci. A Polym. Chem. 2003, 41, 3667-3679. [Pg.2255]

Polyanhydrides can be transformed into poly(anhydride-esters) without degradation of the polymer. The reaction between propylene oxide and a polyanhydride yielded a poly(anhydride-ester) [43]. The reaction was carried out at... [Pg.113]

Salicylic acid-derived poly(anhydride-esters) using a benzyl protected salicylic acid and sebacoyl chloride in a coupling reaction with sodium hydride in tetrahydrofuran (Erdmann and Uhrich, 2000). [Pg.164]

Muggh, D.S., Burkoth, A.K., Keyser, S. A., Lee, H.R., Anseth, K.S., 1998. Reaction behavior of biodegradable, photo-cross-linkable polyanhydrides. Macromolecules 31, 4120—4125. Ouimet, M.A., Griffin, J., Carbone-Howell, A.L., Wu, W.-H., Stebbins, N.D., Di, R., Uhrich, K.E., 2013. Biodegradable ferulic acid-containing poly (anhydride-ester) degradation products with controlled release and sustained antioxidant activity. Biomacromolecules 14, 854—861. [Pg.186]

K. Whltaker-Brothers, K. Uhrich, Poly(anhydride-ester) fibers role of copolymer composition on hydrolytic degradation and mechanical properties. J. Biomed. Mater. Res. Part A 70A(2), 309-318 (2004)... [Pg.42]

Polyanhydride structures can be modified by the addition of aminoacids, linked via imide bonds at the amino terminus, so that the carboxylic acid terminus remains available for the interaction with acetic anhydride [459]. These poly(anhydride-imides) degrade in a similar way as the simple polyanhydride polymers. Other modifications that can take place are copolymers linked with esters. In that way, the polymer contains two types of hydrolytically cleavable bonds. In the presence of water, both types of bonds are hydrolyzed, releasing the dicarboxylic acid and the ester [460]. An example of a poly(anhydride-ester) with application in the medicinal field includes sebacic acid and salicylic acid, a therapeutically useful compound. The release of sebacic acid in the body opens up a variety of potential applications. [Pg.169]

IDEAL/ Bioabsorbable Therapeutics, Menlo Park, CA poly-anhydride ester + salicylate 3/9-12 8.3 pg/mm 100%, 30... [Pg.423]

In addition, polyanhydrides have been considered as attractive materials for temporary biomaterials, such as sutures, and bioabsorbable prostheses. Degradation products of these polymers have anti-thrombotic/anti-inflammatory properties. Active polymers namely poly(anhydride esters) stimulate new tissue formation. The resulting combination features make polyanhydrides as ideal implantable materials. [Pg.337]

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