Polio virus type antiviral activity

Out of six amathaspiramides, only four amathaspiramides A-C (129-131) and E (133) were evaluated for their biological activity as a cytotoxic, antiviral, antimicrobial and for P388 murine leukemic. Amathaspiramides A (129) and E (133) exhibited moderate cytotoxic activity against the BSC-1 cells (1+, 40 pg/well), while amathaspiramides B (130) and C (131) were foimd inactive at the tested concentrations. Amathaspiramide E (133) was found highly active (4+, 40 pg/well) against the Polio virus Type 1 (Pfizer vaccine strain). 

Flavonoids also showed, to some extent, some antifungal and antiviral activity. In this case, there is an important structure-activity relationship. The flavonol quercetin and the flavanone hesperidin exhibit inhibition activity towards the infective capacity and/or replication of herpes simplex type viruses and polio viruses, while the flavanone naringenin totally lacks this ability [124]. For researchers the impossibility to dissociate, the viruses from the flavonol quercetin after 1 hour of interaction, either by dialysis or ultracentrifugation suggests the formation of quercetin-virus complexes, which may have lost the ability to induce infection. With respect to the antiviral activity of the methoxylated flavones, this is strongly related to a substitution pattern based on... 

A were effective against herpes simplex virus-1 (HSV-land 11) [82, 83]. Eudistomin K sulfoxide and eudistomin K have high activities against polio vaccine type-1 virus. Platinum (If) and palladium (11) complexes of harmaline, harmalol, harmine, and harman and ( )-Debromoeudistomin K were also observed to exhibit antiviral activities against influenza virus (A and B) and herpes virus [84]. Recently, harman and its derivatives were found to possess anti-HIV activities against human peripheral blood mmuHiuclear (PBM) cells [85]. 

Lapachol, 11, has interesting antitumor activity (264, 351) as well as in vitro antiviral activity against polio type 1, ECHO type 19, coxsackiae B-4, and several strains of influenza viruses (596). Three novel furonaphthoquinones, 12, 13, and 14, are reported to have cytotoxic effects with ED50 values of 1.0-2.0 pg/ml against the P388 leukemia in vitro (861). 

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