Platinum containing drugs

I. Ensslin, A. Pethran, R. Schieler, G. Frumann, Urinary platinum in hospital pharmacy personnel occupationally exposed to platinum-containing drugs, Int. Arch. Occup. Environ. Health, 65 (1994), 339D342. 

Platinum and its alloys are used in jewelry, dentistry, the chemical industry, and the electrical industry. Most automobile catalytic converters contain platinum. Certain platinum compounds that have the cis configuration and can combine with DNA are useful therapeutic agents for many cancers that do not respond readily to conventional chemotherapy (especially testicular, ovarian, bladder, prostate, and thyroid cancers). Testicular cancer, which was once always fatal, now responds to platinum-containing drugs. 

Metal Complexes - The Fourth International Symposium on Platinum Coordination Complexes in Cancer Chemotherapy covered various aspects of the synthesis, biochemistry, pharmacology, toxicology and clinical evaluation of platinum containing drugs. A study correlating the structure of platinum complexes with activity, toxicity, and lability has appeared. 

P.J. Parsons, P.F. Morrison and A.F. LeRoy, Determination of platinum-containing drugs in human plasma by liquid chromatography with reductive electrochemical detection, J. Chromatogr., 1987, 385, 323-335. 

Maleic copolymers were proved to form chelates with platinum-containing anticancer drugs (cis-diamminedichloroplatinum(II), trans-l,2-diaminocyclohexane platinum) through a monocarboxylato and a 0->Pt coordination linkage. These complexes self-assembled into nanoparticles with an increased in-vivo tumors inhibition due to their internalization into the cancer cells. The release of the platinum-containing drug was pH dependent [211,212]. 

Polymeric Platinum-Containing Drugs in the Treatment of Cancer... 

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