Platinum compounds J

Robertson JM (1935) An X-ray study of the structure of the phthalocyanines. Part I. The metal-free, nickel, copper, and platinum compounds. J Chem Soc 615-621... 

Beevers, C. A., and Lipson, H. Crystal structure of copper sulphate pentahy-drate, CuS04-5H20. Proc. Roy. Soc. (London) A146, 570-582 (1934). Robertson, J. M. An X-ray study of the structure of the phthalocyanines. Part I. The metal-free, nickel, copper and platinum compounds. J. Chem. Soc. (London) 615-621 (1934). 

The organic bases form, like ammonia, crystalline chloroplati-nates with platinic chloride of the general formula BoH,j,PtCl,). By estimating the amount of platinum present in the salt, it is possible to calculate the molecular weight of the platinum compound, and consequently that of the base. 

The mechanism of action of antitumour platinum coordination compounds. J. J. Roberts, Adv. Inorg. Biochem., 1981, 3, 273-332 (141). 

Natile, G. Coluccia, M. Trans-platinum Compounds in Cancer Therapy A Largely Unexplored Strategy for Identifying Novel Antitumor Platinum Drugs In Metallopharmaceuticals l DNA Interactions, Clarke, M. J. Sadler, P. I, Eds. Springer-Verlag Berlin, 1999 Vol. 1, pp 73-98. 

Richmond TJ, Widom J (2000) Nucleosome and chromatin structure. Oxford University Press, Oxford Roberts JJ, Thomson AJ (1979) The mechanism of action of antitumor platinum compounds. Prog Nucleic Acid Res Mol Biol 22 71-133... 

Rosenberg B, VanCamp L, Trosko J, Mansour VH. Platinum compounds a new class of potent antitumour agent. Nature 1969 222 385-386. 

Alkylideneamido ligands can be formed from the precursor compound Me3SnN=CR2 Reaction with platinum compounds gives both the j/2-type complexes (Ph3)2Pt(i72-HN=CR2 and the complexes containing the R2CN ligand of type Pt(N=CR2)(PPh3)2.1184 1185... 

Gilman, H. et al., J. Amer. Chem. Soc., 1953, 75, 2065 It explodes sharply in a shower of sparks on heating. See Other ALKYLMETALS, PLATINUM COMPOUNDS... 

Ruiz J, Lorenzo J, Sanglas L, Cutillas N, Vicente C, Villa MD, Aviles FX, Lopez G, Moreno V, Perez J, Bautista D (2006) Palladium(II) and platinum(II) organometallic complexes with the model nucleobase anions of thymine, uracil, and cytosine antitumor activity and interactions with DNA of the platinum compounds. Inorg Chem 45 6347-6360... 

Ruiz J, Villa MD, Cutillas N, Lopez G, de Haro C, Bautista D, Moreno V, Valencia L (2008) Palladium(II) and Platinum(II) Organometallic Complexes with 4, 7-dihydro-5-methyl-7-oxo[l, 2, 4]triazolo[l, 5-a]pyrimidine. Antitumor activity of the platinum compounds. Inorg Chem 47 4490 1505... 

Casini A, Gabbiani C, Michelucci E, Pieraccini G, Moneti G, Dyson PJ, Messori L (2009) Exploring metallodrug-protein interactions by mass spectrometry comparisons between platinum coordination complexes and an organometallic ruthenium compound. J Biol Inorg Chem 14 761-770... 

Soriaga, M. P. and Hubbard, A. T. (1982) Determination of the orientation of adsorbed molecules at solid-liquid interfaces by thin-layer electrochemistry Aromatic compounds at platinum electrodes. J. Am. Chem. Soc. 104, 2735-2742. 

Iloranyi. G.(1974) On the adsorption of organic compounds on platinized platinum electrodes. J. Electroanal. Chem. 51, 163-178... 

K. E. Sandman and S. J. Lippard, Activity of Platinum Compounds in Comhinatorial Libraries, in 30 Years of Cisplatin, Chemistry and Biochemistry of a Leading Anticancer Drug , ed. B. Lippert, Whey VCH, Weinheim, 1999, p. 523. 

Barefoot, R.R. Speciation of platinum compounds a review of recent applications in studies of platinum anticancer drugs. J. Chromatogr. B 751, 205-211 (2001)... 

Goodisman, J., Hagrman, D., Tacka, K.A., Souid, A.K. Analysis of cytotoxicities of platinum compounds. Cancer Chemother. Pharmacol. 57, 257-267 (2006)... 

Harder HC, Rosenberg B. Inhibitory effects of anti-tumor platinum compounds on DMA, RNA,and protein synthesis In mammalian cells in vitro. Int J Cancer 1970 6 207-16. 

Hannemann J, Baumann K. Inhibition of lactate-dehydrogenase by cisplatin and other platinum- compounds enzyme leakage of LDH is not a suitable method to measure platinum-compound-induced kidney cell damage in vitro. Res Commun Chem Pathol Pharmacol 1988 60 371-379. 

Platinum compounds without antitumor activity (17) such as t2 ons-DDP and [Pt(dien)Cl]Cl (Figure 1) covalently bind to DNA in vivo. Several studies have compared the biological effects which result when equal amounts of these three platinum compounds are fixed on DNA (typically r j 10" -10"6), Cis-DDP is 5-10 times more toxic toward E, ooli ( ) and mammalian cells (j, U.) than t2 ans-DDP, The relative toxicity is correlated with the ability of these two isomers to inhibit DNA replication (, i3, J 4). The ois isomer is repaired more efficiently by E, ooli W and is at least 750 times more mutagenic in mammalian cells (11) than the trans isomer. The compound [Pt(dien)Cl]Cl binds covalently to the DNA of E, ooli and seems not to be repaired nevertheless this compound does not inhibit DNA synthesis or kill the bacteria ( ), Repair of platinum compounds by E, ooli may be under the control of the SOS system c s-DDP induces 5-10 times more recA protein in treated E. Coli than an equal amount of trans-DPP or [Pt(dien)Cl]Cl fixed on the DNA (18), It seems that different modes of fixation on DNA are responsible for the different mutagenicity, toxicity and DNA repair of these platinum complexes. These results suggest that the antitumor activity of platinum(II) compounds may also depend on the formation of particular platinum-DNA lesions. 

If aqueous solutions of eis- or traws-DDP are allowed to equilibrate, the kinetics of the reactions of these equated species with DNA can be measured Atlow r j the reaction is pseudo-first-order with respect to platinum concentration. For eis-DDP, the half-life of the reaction of the diaquo species with 10"4 M DNA at 25 C, pH 5-6 is 0,8 min and the monoaquo species, and t2 ans-[Pt(NH3)2(H20)Cl]J have half-lives of 6 h and 2 h respectively The forms [Pt(NH3)2Cl(OH)] and [Pt(NH3)2(OH)2] do not react with DNA and ais-[Pt(NH372 (H2O) (OH) ]" reacts with the same kinetics as the diaquo form (20). However, if freshly dissolved solutions of platinum compounds are added to the DNA, formation of the monoaquo species is the rate limiting step (22). Figure 2 shows the reactions of fresh solutions of the three compounds with DNA at 37 C Under these conditions the half-lives of the reactions were 3.9, 2.5 and 0.65 h for ais-DDP, trons-DDP and [Pt(dien)Cl]Cl respectively (19). 

Chibbee R and Oed MJ (1989) The mutagenic and carcinogenic properties of three second generation antitumour platinum compounds a comparison with cisplatin. Eur J Cancer Clin Oncol 25 27-33. 

Cleaee MJ, Hughes EG, Jacoby B and Pepys J (1976) Immediate (type I) aUergtc responses to platinum compounds. Clin Allergy 6 183—195. 

Bruhn, Suzanne L., Toney, Jeffrey H., and Lippard, Stephen J., Biological Processing of DNA Modified by Platinum Compounds 38 477... 

Griffin MR, Yared A, Ray WA (2000) Nonsteroidal antiinflammatory drags and acute renal failure in elderly persons. Am J Epidemiol 151 488-496 Hartmann JT, Lipp HP (2003) Toxicity of platinum compounds. Expert Opin Pharmacother 4 889-901... 

Harder, H. C. Rosenberg, B., Inhibitory Effects of Antitumor Platinum Compounds on DNA, RNA, and Protein Synthesis in Mammalian Cells In Vitro, Int. J. Cancer, 1970, 207-216. 

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