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Platelet-derived growth factor B-chain

GI 129724 Platelet-derived growth factor, B chain precursor adequate blood supply... [Pg.489]

Khachigian LM, Resnick N, Gimbrone MA Jr, Collins T. Nuclear factor-KB interacts functionally with the platelet-derived growth factor B-chain shear-stress response element in vascular endothelial cells exposed to fluid shear stress. / Clin Invest. 1995 96 1169-1175. [Pg.255]

Resnick N, Collins T, Atkinson W, Bonthron DT, Dewey CF Jr, Gimbron MA. Platelet-derived growth factor B chain promoter contains cis-acting fluid shear-stress responsive element. Proc Natl Acad Sci USA. 1993 90 7908. [Pg.258]

Green LS, Jellinek D, Jenison R, Eldin CH, Janjic N, Inhibitory DNA ligands to platelet-derived growth factor B-chain, Biochemistry, 35 14413-14424, 1996. [Pg.516]

Collins T, Ginsburg D, Boss JM, Orkin SH, Pober J (1985) Cultured human endothelial cells express platelet-derived growth factor B chain cDNA cloning and structural analysis. Nature 316 748-750... [Pg.313]

Lindner V, Giachelli CM, Schwartz SM, Reidy MA (1995) A subpopulation of smooth muscle cells ininjured rat arteries expresses platelet-derived growth factor-B chain mRNA. Circ Res 76 951-957... [Pg.317]

Majesky MW, Benditt EP, Schwartz SM (1988) Expression and developmental control of platelet-derived growth factor A-chain and B-chain/Sis genes in rat aortic smooth muscle cells. Proc Natl Acad Sci USA 85 1524-1528... [Pg.310]

A. General description Becaplermin, a recombinant human platelet-derived growth factor (rhPDGF-BB), is produced by recombinant DNA technology by insertion of the gene for the B chain of PDGF into the yeast Saccharomyces cerevisiae. [Pg.331]

Platelet-derived growth factors (PDGFs) exist in three different dimeric compositions, containing disulphide-linked A-, or B-, or A- and B-chains (AA, BB, or heterodimeric... [Pg.11]

Fig. 8.6 Heterodimerization of PDCF receptors, a) There are a and / subtypes of platelet derived growth factor receptor (PDCF-R) these are induced by ligand binding to form homodimers and heterodimers, b) Platelet derived growth factor (PDCF) is a dimeric growth factor, composed of chains A and/or B. The protein may exist as a homodimer (AA, BB) or heterodimer (AB). The AA homodimer of PDCF binds to the aa dimer of PDCF-R, AB binds to the aa and a 3 types, BB binds to all three combinations. Fig. 8.6 Heterodimerization of PDCF receptors, a) There are a and / subtypes of platelet derived growth factor receptor (PDCF-R) these are induced by ligand binding to form homodimers and heterodimers, b) Platelet derived growth factor (PDCF) is a dimeric growth factor, composed of chains A and/or B. The protein may exist as a homodimer (AA, BB) or heterodimer (AB). The AA homodimer of PDCF binds to the aa dimer of PDCF-R, AB binds to the aa and a 3 types, BB binds to all three combinations.
Claesson-Welsh, L. Eriksson, A. Moren, A. Severinsson, L. Ek, B. Ost-man. A. Betsholtz, C. Heldin, C.H. cDNA cloning and expression of a human platelet-derived growth factor (PDGF) receptor specific for B-chain-containing PDGF molecules. Mol. Cell. Biol., 8, 3476-3486 (1988)... [Pg.585]

CYP163B3 (P450sky) from Streptomyces sp. Acta 2897 is involved in the biosynthesis of the cyclic depsipeptides skyllamycin A and B, with antibacterial, immunosuppressive, cytostatic, and antiparasitic properties [233], Skyllamycin A has been isolated from different Streptomyces strains and is a potent inhibitor of the platelet-derived growth factor (PDGF) signaling pathway that is involved in important processes such as cellular proliferation and migration [234, 235]. The structure of skyllamycin has an unusual a-hydroxylated glycine residue, an N-terminal cinnamoyl side chain, and three P-hydroxylated amino acids ((25, 55)-p-hydroxyphenylalanine,... [Pg.295]

See other pages where Platelet-derived growth factor B-chain is mentioned: [Pg.329]    [Pg.173]    [Pg.329]    [Pg.173]    [Pg.146]    [Pg.267]    [Pg.287]    [Pg.293]    [Pg.432]    [Pg.572]    [Pg.1755]    [Pg.215]    [Pg.145]    [Pg.8]    [Pg.905]    [Pg.572]    [Pg.206]    [Pg.641]    [Pg.236]    [Pg.212]    [Pg.1196]   


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B-factors

Chain-Growth

Derivatives (B)

Factors chain

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