Human platelet-derived growth factor

Direct laser-assisted myocardial revascularization (DMR) is an approved technique in the US, Europe, and parts of Asia to create numerous myocardial channels. This results in the induction of a massive inflammatory reaction, which in turn induces angiogenesis. The other FDA-approved pro-angiogenic therapy is the use of recombinant human platelet-derived growth factor (Regranex) for use in the treatment of diabetic neuropathic foot ulcer s. [Pg.88]

Becaplermin is a recombinant human platelet derived growth factor . It is used to promote the granulation of diabetic, primarily neuropathic, chronic ulcers. Despite the low absorption and short elimination half-life, use during pregnancy and lactation is advised against. [Pg.483]

C. Hydroquinone inhibits the enzyme tyrosine kinase, which converts tyrosine to melanin. It also damages melanocytes. Becaplermin (A) is a recombinant human platelet-derived growth factor that is useful in enhancing wound healing. Etanercept (B) is a recombinant fusion protein approved for treatment of psoriatic arthritis and rheumatoid arthritis. Botulinum toxin (D) is a purified form of bofu-linum foxin fype A approved for fherapy of blepharospasm and sfrabismus. [Pg.497]

Chemical Class Recombinant human platelet-derived growth factor (rhPDGF-BB)... [Pg.118]

A. General description Becaplermin, a recombinant human platelet-derived growth factor (rhPDGF-BB), is produced by recombinant DNA technology by insertion of the gene for the B chain of PDGF into the yeast Saccharomyces cerevisiae. [Pg.331]

Miller, M.S. Use of topical recombinant human platelet-derived growth factor-BB (becaplermin) in healing of chronic mixed arteriovenous lower extremity diabetic ulcers. J. Foot Ankle Surg. 1999, 38 (3), 227-231. [Pg.301]

A Tran, H Parker, V Levi, M Kunitani. Analysis of recombinant human platelet-derived growth factor by reversed-charge capillary zone electrophoresis. Anal Chem 70 3809-3817, 1998. [Pg.397]

Human platelet-derived growth factor, see PDGF Human protein processing 774 Human retinal pigment epithelial (hRPE) 325 Human serum albumin (HSA) 275 Human somatic cell nuclear transfer 273 Human tissue plasminogen activator... [Pg.1861]

Claesson-Welsh, L. Eriksson, A. Moren, A. Severinsson, L. Ek, B. Ost-man. A. Betsholtz, C. Heldin, C.H. cDNA cloning and expression of a human platelet-derived growth factor (PDGF) receptor specific for B-chain-containing PDGF molecules. Mol. Cell. Biol., 8, 3476-3486 (1988)... [Pg.585]

The amplification of many other DNA sequences has been carried out by transfection of a cloning vector into a bacterial cell, making it possible to produce quantities of natural proteins that were not previously available, as well as unknown proteins. Green fluorescent protein (see Section 25.19) and its derivatives are produced by recombinant DNA technology. A recombinant human-platelet-derived growth factor (rh-PDGF) becaplermin (Regranex) is used clinically in the treatment of diabetic skin ulcers. [Pg.1204]

Castor, C. W., Miller, J. W. and Walz, D. A. (1983). Structural and biological characteristics of connective tissue activating peptide (CTAP-III), a major human platelet-derived growth factor. Proc. Natl. Acad. Sci. USA 80,765-769. [Pg.206]

Steed, D.L., Study Group, t.D.U. Clinical evaluation of recombinant human platelet— derived growth factor for the treatment of lower extremity diabetic ulcers. J. Vase. Surg. 21(1), 71-81 (1995)... [Pg.428]

Mome DC, Ehrlich MG, McAllister SC et al (2009) Recombinant human platelet-derived growth factor-BB augmentation of new-bone formation in a rat model of distraction osteogenesis. J Bone Joirrt Srrrg Am 91 1973-1984... [Pg.229]

Habenicht AJR, Goerig M, Grulich J, Rothe D, Gronwald R, Loth U, Schettler G, Kommerell B, Ross R (1983) Human platelet-derived growth factor stimulates prostaglandin synthesis by activation and by rai d de novo synthesis of cyclooxygenase. J Clin Invest 73 1381-1387... [Pg.30]

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