Platelet count, normal range

Patients receiving IFN experience side effects similar to influenza symptoms headache, nausea and tiredness. IFN also decreases red blood cells, white blood cells and platelet counts. A measure of the effectiveness of IFN treatment is the marker called alanine aminotransferase in blood. The normal range is 10-70 U/L. 

Thrombocytopenia - Linezolid has been associated with thrombocytopenia when used in doses of 600 mg or less every 12 hours for up to 28 days. Thrombocytopenia associated with the use of linezolid appears to be dependent on duration of therapy (generally more than 2 weeks of treatment). The platelet counts for most patients returned to the normal range/baseline during the follow-up period. 

Laboratory tests showed that hemoglobin was 7.5 g/dL (normal range is 12-15 g/dL), and the reticulocyte count was 262 x 109/L (normal range is 50-100 X 109/L). The tests also indicated neutrophilia, a white cell count of 34 X 109/L (normal range is 4-11 x 109/L), and a platelet count of 328 X 109/L (normal range is 150-400 X 109/L). Renal function was normal. Malarial parasite screen and direct Coombs test were negative. Blood film showed nucleated red blood cells and anisocytosis with bite cells ... 

The presence of greater than normal amounts of thrombocytes in the circulation is known as thrombocytosis and along with reticulocytosis and leukocytosis is a manifestation of increased activity of the hematopoietic system. Zucker and Woodard (Z2) reported a series of 12 patients with thrombocytosis, consisting of two cases of polycythemia vera, three of essential thrombocytemia, three of chronic granulocytic leukemia, one myeloproliferative syndrome, one erythroleukemia, and one cancer of the bladder. The platelet counts ranged from 685 X 10 to 2500 X 10 per cubic millimeter, all much above the upper limit of normal. 

A low pretreatment platelet count, the dose of interferon alfa, and the haptoglobin phenotype are risk factors for ribavirin-induced anemia, and the fall in hemoglobin is independent of dose in the therapeutic range (16). In five patients with chronic hepatitis C on hemodialysis who received subcutaneous interferon alfa-2b and oral ribavirin for 40 weeks, the dose of ribavirin was titrated based on hemoglobin, with bone marrow support by erythropoietin (17). There was significant bone marrow toxicity in all five. A dose of 200 mg/day produced a steady-state AUC comparable to that obtained with 1000-1200 mg/ day in historical controls with normal renal fnnction. More severe anemia was possibly due to chronic renal insufficiency in addition to the prolonged effects of ribavirin. 

Blood samples at the end of treatment revealed no significant net change in red blood cell counts, white blood cell counts, platelets, or hematocrit. The concentrations of albumin, uric acid, bilirubin, and liver enzymes remained within the normal range. Plasma free hemoglobin levels were less than 0.2 g/dL. The level of high-density lipoproteins showed no significant change with treatment (58). 

Patients usually do not have abnormalities in the hematocrit, hemoglobin, or platelet levels. The peripheral white blood cell count may range between 5,000 and 22,000 cells per microliter, but it is usually only mildly elevated. Differential blood cell counts are usually normal, although patients may have a lymphocytosis late in the disease.13 67 Patients may have microscopic pyuria, which may lead to the erroneous diagnosis of a urinary tract infection.13,68 Mild elevations in lactic dehydrogenase, serum transaminases, and alkaline phosphatase are commonly seen. Some patients may experience rhabdomyolysis associated with elevations in the serum creatine kinase and urinary myoglobin lev-... 

A pronounced drop was observed in the blood platelet count of subjects given HEAR oil and margarine as essentially the sole source of dietary fat for 22 days (Table VI). Blood platelet counts dropped to values that were considered to be below normal for five of the seven subjects on this regimen. Platelet counts in what was the low normal range (120,000-150,000/mm ) also were observed in the LEAR oil group but no consistent pattern devel-... 

Red cell, white cell, platelet counts, white blood cell differential, hematacrit and red cell indices must be performed by an accredited laboratory. The normal ranges for the red cell and white cell counts are influenced by altitude, race, and sex, and therefore should be determined by the acaedited laboratory in the specific area where the tests are performed. 

Fig. 16.3a-c. A 47-year-old woman with locally advanced pancreatic carcinoma and thrombocytopenia, precluding further chemotherapy, was referred for partial splenic embolization. Pre-embolization arteriogram (a) shows normal splenic artery anatomy. The superior splenic artery (b) was selectively catheterized and embolized using particles (range, 300-500 microns). Post-embolization arteriogram (c) shows complete occlusion of the superior splenic artery. One month after embolization, her platelet count was greater than 400,000/mm ... 

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