Plasma lipoproteins reference concentrations

The most commonly used index of vitamin E nutritional status is the plasma concentration of a-tocopherol because it is transported in plasma lipoproteins, it is best expressed per mole of cholesterol or per milligram of total plasma lipids (Horwitt et al., 1972 Winbauer et al., 1999). The reference range is... 

Apart from the hyperlipoproteinaemias that act as determinants of abnormal plasma lipoprotein concentrations, conditions with abnormally low concentrations of certain lipoproteins are also encountered and are generally referred to as the hypolipoproteinaemias. Tangier disease is one such condition that occurs as a rare inherited condition with autosomal recessive characteristics. The condition, a familial HDL deficiency, is characterized by cholesteryl ester accumulation in the reticuloendothelial system, which is similar in pattern to other lipid-storage diseases, such as gangliosidoses. Atheroma are substantially absent from the aorta and coronary vessels of such patients. The plasma cholesterol concentration is reduced and the triacylglycerol concentration is normal or increased in these cases. 

Only nine years after its discovery in plasma as an antigenic trait, a relationship was suggested between lipoprotein(a) and coronary heart disease (CHD) (B6, D2). Moreover, an interesting relationship between longevity and Lp(a) concentrations was reported by Berg (B10) The frequency of higher Lp(a) levels in very old persons (>83 years) was lower than in the reference population. The same observation was made by Knapp (K18) in black American men. This... 

Plasma lipid and lipoprotein concentrations in male and female subjects are presented in Tables 26-7 through 26-10. These reference intervals have been developed using the Lipid Research CHnics (LRC) population. Although reference intervals for apo A-I and B-lOO from the Framingham Heart Study using the approved World Health Organiza-tion/Internationai Federation of Clinical Chemistry and Laboratory Medicine (IFCC) calibrators have been published,distributions of these two proteins that better reflect the North American population have only recently... 

---