Plants, tumorigenic

There was no evidence that MOCA was tumorigenic in a study of 31 active workers exposed from 6 months to 16 years. Quantitative analysis of the workers urine confirmed exposure to the chemical. In addition, the records were reviewed for 178 employees who at one time had worked with MOCA but who thereafter had had no further exposure for at least 10 years. The general health of exposed workers with respect to illness, absenteeism, and medical history was similar to that of the total plant population. Two deaths in this group due to malignancy had been diagnosed before any work with or exposure to MOCA. For the plant population in general, there were 115 cancer deaths/100,000 over a 15-year period... 

SAFETY PROFILE Some are experimental neoplastigens and tumorigens. Lead poisoning is one of the commonest of occupational diseases. The presence of leadbearing materials or lead compounds in an industrial plant does not necessarily result in exposure on the part of the worker. The lead must be in such form, and so distributed, as to gain entrance into the body or tissues of the worker in measurable quantity otherwise no exposure can be said to exist. Some lead compounds are carcinogens of the lungs and kidneys. 

Weyand EH, Chen Y-C, Wu Y, et al. 1995. Differences in the tumorigenic activity of a pure hydrocarbon and a complex mixture following ingestion Benzo[a]pyrene vs manufactured gas plant residue. Chem Res Toxicol 8 949-954. 

The alcohol category in tobacco and tobacco smoke includes the phytosterols, the plant-derived sterols. The sterols have been examined in considerable detail over the years, an examination that did not actually originate in the study of tobacco and/or its smoke. In 1928, Kennaway and Sampson demonstrated the tumorigenicity of the pyrolysate from the sterol cholesterol (2080). Their study preceded the first reports of induction of skin cancer in laboratory animals with two individual compounds, the PAHs dibenz[a,fi]anthracene (DB[fl,/i]A) in 1930 by Kennaway and Hieger (2078) and benzo[fl]pyrene (B[a]P) in 1932 by Cook et al. (796a, 797). Both PAHs subsequently were classified as highly potent tumorigens. Based on the results of their detailed study of the... 

The constituents of the tumorigenic plant Melochia tomentosa include 6-methoxy-7,8-methylenedioxycoumarin, three cyclopeptide alkaloids, melo-chinone (a quinolinone derivative), and two novel phenylpentyl-isatins, melosatins A and B, for which the structures (3) and (4) have been deduced. The structure of melosatin A was confirmed by synthesis (Scheme 1),... 

Kosuge, T. and M. Sanger, Indoleacetic acid, its synthesis and regulation A basis for tumorigenicity in plant disease, in The Shikimic Acid Pathway (E. E. Conn, ed.). Recent Advances in Phytochemistry Vol. 20 147-161, Plenum Press, New York, 1986. 

Melochia tomentosa, a tumorigenic plant of the Sterculia-ceae, has been shown to contain the alkaloids melosatin A and B (44, 45) that contain an indole nucleus and are quite unusual in stracture (Kapadia et al., 1977). 

INDOLEACETIC ACID, ITS SYNTHESIS AND REGULATION FOR TUMORIGENICITY IN PLANT DISEASE... 

The association between lAA production and virulence is also apparent in the interaction between the tumorigenic bacterium, P. savastanoi, and its hosts, oleander and olive. Production of lAA confers virulence in P. savastanoi because mutants deficient in lAA production fail to incite the production of tumors on oleander plants. When genes for lAA production are transferred from parental strains to these mutants, both lAA synthesis and full virulence are restored. Since loss of lAA production is not lethal to the bacterium, lAA synthesis constitutes secondary metabolism of tryptophan in the bacterium. In contrast to A. 

Mutations by insertional inactivation are responsible for the change of phenotype in other plant pathogenic bacteria. Loss of tumorigenicity has been observed in A. tumefaciens by spontaneous insertion of an IS-element in the T-DNA. It should be recalled that Tn5 insertional inactivation of the T-DNA genes was used to isolate mutants which either were avirulent or caused formation of morphologically altered tumors on tobacco different hosts of Agrobacterium. 

Inula, from Compositae, has more than 100 species in the world, mainly found in Europe, Africa and Asia. There are more than 20 species in China. Inula britannica is a wild plant found in Eastern Asia, including China, Korea, and Japan. In traditional Chinese medicine. Inula britannica and Inula japonica are called Xuanfiihua and the flowers have been used for the treatment of digestive disorders, bronchitis and inflammation. Its extracts are reported to have anti-inflammatory, anti-bacteria, anti-hepatitis and anti-tumorigenic activities ) ... 

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