Antithrombotic action

Gleitz J, Beile A, Wilkens P, Ameri A, Peters T. (1997). Antithrombotic action of the kava pyrone (+)-kavain prepared from Piper methysticum on human platelets. Planta Med. 63(1) 27-30. 

Pharmacology Antithrombotic action is the result of the additive antiplatelet effects of dipyridamole and aspirin. 

C) The antioxidant actions of flavonoids appear to participate in their antithrombotic action. Flavonoids bind to platelet membranes and scavenge platelet-generated lipid peroxides and free radicals, restoring the biosynthesis and the action of endothelial prostacyclin and nitric oxide (NO), respectively [49,88]. 

Antithrombotic action Thrombin = Xa Thrombin Fibrin-bound, free-thrombin Thrombin Fibrin-bound, free-thrombin Thrombin Fibrin-bound, free-thrombin... 

G. E, Felton. Fibrinolytic and antithrombotic action of bromelain may eliminate thrombosis in heart undents. Med. Hvootheaea 6 1123 (19801. 

Breddin HK (1989) Thrombosis and Virchow s Triad What is established. Semin Thromb Haemost 15 237-239 Fareed J, Walenga JM, Kumar A, Rock A (1985) A modified stasis thrombosis model to study the antithrombotic action of heparin and its fractions. Semin Thromb Hemost 11 155-175... 

Chemical modification of the unfiactionated heparin, such as desul tion, deamination and coupling with various agents have resulted in products of non-anticoagulant nature with selective actions on enzymes and cellular receptors. Thioxyloside derivatives have also been reported to produce oral antithrombotic actions in animal models. However, relatively larger dosages are needed to produce these effects. These heparin derivatives are currently tested for such indications as sepsis, viral infections and the treatment of proliferative disorders. 

Cambridge H, Lees P, Hooke R E et al 1991 Antithrombotic actions of aspirin in the horse. Equine Veterinary Journal 23 123-127... 

Ginger is shown to have an antithrombotic action, reducing clotting and the risk of stroke and vessel infarct. It also has been shown to decrease blood pressure. 

The antioxidant actions of flavonoids appear to be involved in their observed antithrombotic action [50-52]. The antithrombotic and vasoprotective actions of quercetin, rutin, and other flavonoids have been attributed to their ability to bind to platelet membranes and scavenge free radicals [50]. In this manner, flavonoids restore the biosynthesis and action of endothelial prostacyclin and endothelialderived relaxing factor (EDRF), both of which are known to be inhibited by free radicals [50, 53, 54]. However, some flavonoids may inhibit arachidonic acid metabolism and platelet function by flavonoid-enzyme interactions rather than by antioxidant effects [55]. In addition to their antiaggregatory effects, flavonoids appear to increase vasodilation by inducing vascular smooth muscle relaxation, which may be mediated by inhibition of protein kinase C, PDFs, or by decreased cellular uptake of calcium [56]. 

Gryglewski RJ, Korbut R, Robak J, Swies J. On the mechanism of antithrombotic action of flavonoids. Biochem Pharmacol 1987 36 317-322. 

Buijsman, R. C., Basten, J. E., van Dinther, T. G., van der Marel, G. A., van Boeckel, C. A., van Boom, J. H. Design and synthesis of a novel synthetic NAPAP-pentasaccharide conjugate displaying a dual antithrombotic action. Bioorg. Med. Chem. Lett 1999, 9,2013-2018. 

In addition to lowering plasma TG, n-3 fatty acids (eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)) are reported to have a number of additional beneficial effects on the cardiovascular system which include antihypertensive and antithrombotic actions. EPA and DHA are major fatty acid constituents of fish oil and it has been assumed that both EPA and DHA are responsible for its hypotriglyeeridemic activity. However, growing evidence indicates that EPA and DHA may possess different hypohpidemic properties. We have reported that EPA is the fatty add primarily responsible for the TG-lowering effect of fish oil (Table 1), but the mechanism underlying this hypotriglyceridemic effect has not yet been fully elucidated. Interestingly, however, we... 

A review of the literature on the possible antithrombotic action of such platelet function inhibitors as aspirin, dipyridamole, sulfinpyrazone, and clofibrate, reveals that the great m ority of the trials performed have given negative results, and that none of the positive reports have been confirmed (19 ). This implies that the interference of these agents with haemostatic plug formation is... 

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