Kava pyrones

Davies LP, Drew CA, Duffield P, Johnston GA, Jamieson DD. (1992). Kava pyrones and resin studies on GABAA, GABAB and benzodiazepine binding sites in rodent brain. Pharmacol Toxicol. 71(2) 120-26. 

Gleitz J, Beile A, Wilkens P, Ameri A, Peters T. (1997). Antithrombotic action of the kava pyrone (+)-kavain prepared from Piper methysticum on human platelets. Planta Med. 63(1) 27-30. 

Kretzschmar R, Meyer HJ. (1968). Der EinfluB naturlicher 5,6-hydrierter Kava-Pyrone auf isolierte Herzpraparate und irhe antifibrallatorische Wirkung am Ganztier. Arch Int Pharmacodyn Ther. 177 261-77. 

Kretzschmar R, Meyer HJ, Teschendorf HJ, Zollner B (1969). [Antagonistic action of natural 5,6-hydrogenated kava pyrones against strychnine poisoning and experimental local tetanus]. Arch Int Pharmacodyn Ther. Dec. 182(2) 251-68. 

Seitz U, Schule A, Gleitz J. (1997). [3H]-monoamine uptake inhibition properties of kava pyrones. Planta Med. 63(6) 548-49. 

Uebelhack R, Franke L, Schewe FIJ. (1998). Inhibition of platelet MAO-B by kava pyrone-enriched extract from Piper methysticum Forster (kava-kava). Pharmacopsychiatry. 31(5) 187-92. 

Chemical Name (R-(E))-5,6-Dihydro-4-methoxy-6-styryl-2H-pyran-2-one Common Name Cavain Gonosan Kavain Kava pyrone Kawain Structural Formula ... 

Alpinia zerumbet (Pers.) B.L. Burtt R.M. Sm. - leopoldina Nervousness Tea Afro-Brazilians [41] Essential oils [242,243] kava-pyrones [244] flavonoids [245] labdane diterpenes [246,247] ... 

Tfoiing, R.L. et al. 1966. Analysis of kava pyrones in extracts oiPipermethysticum Phytochemistry 5 795—798. 

Kava kava. Piper methysticum (Piperaceae), is a large shrub widely cultivated in Oceania. The dried rhizome and root are used in preparation of an intoxicating beverage. Kava contains 5-10% resin, made up of lactones known as kava pyrones—mainly kavain and methystidn. 

Kava pyrones are potent, centrally acting skeletal muscle relaxants. They act as hypnotics, antipyretics, sedatives, local anaesthetics, smooth muscle relaxants and antifungal agents. No interaction with benzodiazepine drugs or with moderate consumption of alcohol occurs, nor does kava impair mental alermess. However, continually chewing the root can destroy tooth enamel and eventually becomes habit forming (Bone 1994). 

Schmidt, A. and Molnar, I. Computer-assisted optimization in the development of a HPLC for the analysis of Kava pyrones in Piper methysticum preparation.. Chromatogr. A 948 53, 2002. 

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